1,2,4-Trichlorobenzene

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1,2,4-Trichlorobenzene
1,2,4-trichlorobenzene.svg
1,2,4-trichlorobenzene-3D-vdW.png
Names
IUPAC name
1,2,4-Trichlorobenzene
Identifiers
120-82-1 N
ChEBI CHEBI:28222 N
ChemSpider 12 YesY
Jmol-3D images Image
PubChem 13
UNII 05IQ959M1N YesY
Properties
C6H3Cl3
Molar mass 181.45 g mol−1
Appearance Colorless liquid
Odor aromatic[1]
Density 1.46 g cm−3
Melting point 16.9 °C (62.4 °F; 290.0 K)
Boiling point 214.4 °C (417.9 °F; 487.5 K)
0.003% (20°C)[1]
Vapor pressure 1 mmHg (20°C)[1]
Hazards
Flash point 110 °C (230 °F; 383 K)
Explosive limits 2.5%-6.6% (150°C)[1]
US health exposure limits (NIOSH):
none[1]
C 5 ppm (40 mg/m3)[1]
N.D.[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N verify (what isYesY/N?)
Infobox references

1,2,4-Trichlorobenzene is an organochlorine compound, one of three isomers of trichlorobenzene. It is a derivative of benzene with three chloride substituents. It is a colorless liquid used as a solvent for a variety of compounds and materials.

Production and uses[edit]

Depending on the conditions and additives (e.g., sulfur), it can be the main product from the chlorination of benzene. It is virtually the exclusive product from the chlorination of 1,4-dichlorobenzene. It is also the main product from the dehydrochlorination of hexachlorocyclohexane.[2]

It is useful as a high-temperature solvent, e.g. for GPC of polyolefines such as PE or PP which are otherwise insoluble.

Aside from its use as a solvent, this compound is a useful precursor to dye and pesticides.

Safety[edit]

The LD50 (oral, rats) is 756 mg/kg. Animal studies have shown that 1,2,4-Trichlorobenzene affects the liver and kidney, and is possibly a teratogen.[3] There is no regulated occupational exposure limit for chemical exposure, but the National Institute for Occupational Safety and Health recommends no greater exposure than 5 ppm, over an 8-hour workday.

References[edit]

  1. ^ a b c d e f g "NIOSH Pocket Guide to Chemical Hazards #0627". National Institute for Occupational Safety and Health (NIOSH). 
  2. ^ Beck, U.; Löser, E. (2005), "Chlorinated Benzenes and other Nucleus-Chlorinated Aromatic Hydrocarbons", Ullmann's Encyclopedia of Industrial Chemistry, Weinheim: Wiley-VCH, doi:10.1002/14356007.o06_o03 
  3. ^ CDC - NIOSH Pocket Guide to Chemical Hazards

See also[edit]