1,2-Dimethylhydrazine

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1,2-Dimethylhydrazine
Skeletal formula of 1,2-dimethylhydrazine with all implicit hydrogens shown
Ball and stick model of 1,2-dimethylhydrazine
Names
IUPAC name
1,2-Dimethylhydrazine[2]
Other names
  • N,N'-Dimethylhydrazine[1]
  • sym-Dimethylhydrazine[1]
  • Hydrazomethane[1]
Identifiers
540-73-8 YesY
Abbreviations SDMH[1]
ChEBI CHEBI:73755 N
ChEMBL ChEMBL162921 N
ChemSpider 1282 YesY
Jmol 3D model Interactive image
KEGG C19176 YesY
MeSH 1,2-Dimethylhydrazine
PubChem 1322
UNII IX068S9745 YesY
Properties[3]
C2H8N2
Molar mass 60.10 g·mol−1
Appearance Colourless liquid
Odor Ichtyal, ammoniacal
Density 827.4 kg m−3 (at 20 °C)
Melting point −9 °C (16 °F; 264 K)
Boiling point 87 °C; 188 °F; 360 K
Miscible
Thermochemistry
171.04 J K−1 mol−1
199.15 J K−1 mol−1
−1987–−1978 kJ mol−1
Related compounds
Related compounds
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

1,2-Dimethylhydrazine, or symmetrical dimethylhydrazine, is one of the three isomers of dimethylhydrazine. It is a potent carcinogen that acts as a DNA methylating agent. It is used to induce colon tumors in experimental animals - particularly mice and feline cell samples.[2][4][5]

See also[edit]

References[edit]

  1. ^ a b c d 74-79-3 1,2-Dimethylhydrazine
  2. ^ a b 1,2-Dimethylhydrazine from PubChem
  3. ^ Record of 1,2-Dimethylhydrazin in the GESTIS Substance Database of the IFA, accessed on 21 March 2008
  4. ^ Cruse, J. P.; Lewin, M. R.; Ferulano, G. P.; Clark, C. G. (1978). "Co-carcinogenic effects of dietary cholesterol in experimental colon cancer". Nature. 276 (5690): 822–5. doi:10.1038/276822a0. PMID 723955. 
  5. ^ Wijnands, M.V.W. (1999). "A comparison of the effects of dietary cellulose and fermentable galacto-oligosaccharide, in a rat model of colorectal carcinogenesis: fermentable fibre confers greater protection than non-fermentable fibre in both high and low fat backgrounds". Carcinogenesis. 20 (4): 651–6. doi:10.1093/carcin/20.4.651. PMID 10223195.