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CAS 93101-02-1.svg
Systematic (IUPAC) name
Clinical data
Legal status
  • Legal
CAS Registry Number 93101-02-1 N
PubChem CID: 13373555
ChemSpider 10544260 YesY
Synonyms W-18
Chemical data
Formula C19H20ClN3O4S
Molecular mass 421.91 g/mol
Physical data
Melting point 157 to 158 °C (315 to 316 °F)
 N (what is this?)  (verify)

1-(4-Nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide (W-18) is a potent μ-opioid agonist with a distinctive chemical structure which is not closely related to other established families of opioid drugs. It was invented by the chemists Edward Knaus, Brent Warran and Theodore Ondrus in 1981.[1]

This compound was found to be around 10,000x more potent than morphine in animal studies.[citation needed]

It has never been studied in humans, but would be expected to produce effects similar to those of other potent opioid agonists, including strong analgesia, sedation, euphoria, constipation, itching and respiratory depression which could be harmful or fatal.[original research?] Tolerance and dependence would be expected to develop rapidly based on the potency of the drug, as it is of a similar strength to carfentanil and so would most likely cause pronounced tachyphylaxis following repeated dosing, as is seen with the potent fentanyl analogues.[original research?]

It was recently found to be in several drugs seized by police in Canada. The seized drugs were believed to be a fentanyl analog but after analysis were identified as 1-(4-nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide. This is of great concern to health officials and police due to the extreme potency of this substance.[citation needed]

See also[edit]