1-pyrroline-4-hydroxy-2-carboxylate deaminase

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1-pyrroline-4-hydroxy-2-carboxylate deaminase
EC no.
CAS no.9054-77-7
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC is an enzyme that catalyzes the chemical reaction

1-pyrroline-4-hydroxy-2-carboxylate + H2O 2,5-dioxopentanoate + NH3

Thus, the two substrates of this enzyme are 1-pyrroline-4-hydroxy-2-carboxylate and H2O, whereas its two products are 2,5-dioxopentanoate and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is 1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (decyclizing). This enzyme is also called HPC deaminase. This enzyme participates in arginine and proline metabolism.


  • Singh RM, Adams E (1965). "Enzymatic deamination of delta-1-pyrroline-4-hydroxy-2-carboxylate to 2,5-dioxovalerate (alpha-ketoglutaric semialdehyde)". The Journal of Biological Chemistry. 240 (11): 4344–51. PMID 5845838.
  • Singh RM, Adams E (Nov 1965). "Isolation and identification of 2,5-dioxovalerate, an intermediate in the bacterial oxidation of hydroxyproline". The Journal of Biological Chemistry. 240 (11): 4352–6. PMID 5845839.