3D model (JSmol)
|Molar mass||473.44 g/mol|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
10-Formyltetrahydrofolate (10-CHO-THF) is a form of tetrahydrofolate that acts as a donor of formyl groups in anabolism. In these reactions 10-CHO-THF is used as a substrate in formyltransferase reactions.
Two equivalents of 10-CHO-THF are required in purine biosynthesis, where 10-CHO-THF is a substrate for phosphoribosylaminoimidazolecarboxamide formyltransferase.
Formation from methenyltetrahydrofolate
- CH2H4F + NAD+ CH2H2F + NADH + H+
In the second step 5,10-methenyltetrahydrofolate undergoes hydrolysis:
- CH2H2F + H2O CHO-H2F +
The latter is equivalently written:
- 5,10-methenyltetrahydrofolate + H2O 10-formyltetrahydrofolate
10-CHO-THF is also produced by the reaction
- ATP + formate + tetrahydrofolate ADP + phosphate + 10-formyltetrahydrofolate
This reaction is catalyzed by formate-tetrahydrofolate ligase.
- Voet, Donald (2016). Fundamentals of Biochemistry: Life at the Molecular Level (5th ed.). Wiley. pp. 1006–1007. ISBN 978-1-118-91840-1.
- Peter D. Pawelek, Robert E. MacKenzie (1998). "Methenyltetrahydrofolate Cyclohydrolase Is Rate Limiting for the Enzymatic Conversion of 10-Formyltetrahydrofolate to 5,10-Methylenetetrahydrofolate in Bifunctional Dehydrogenase-Cyclohydrolase Enzymes". Biochemistry. 37: 1109–1115. doi:10.1021/bi971906t.
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