11-Hydroxy-THC
 | |
 | |
| Identifiers | |
|---|---|
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.164.583  |
| Chemical and physical data | |
| Formula | C21H30O3 |
| Molar mass | 330.468 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
  (what is this?) (verify) | |
11-Hydroxy-Δ9-tetrahydrocannabinol (11-OH-THC), usually referred to as 11-hydroxy-THC, is the main active metabolite of tetrahydrocannabinol (THC), which is formed in the body after decarboxylated cannabis is consumed.[1][2]
Fresh cannabis contains tetrahydrocannabinolic acid (THCA), which is converted into THC after heating and then metabolized by the body into 11-hydroxy-THC and then into 11-nor-9-carboxy-THC;[2] both compounds can be glucuronidated and mainly excreted into urine. Both compounds, along with THC, are assayed in blood tests.[1]
11-hydroxy-THC has a similar psychoactive effect as THC but with a much faster onset of effect.[3] According to animal studies, 11-hydroxy-THC may also have a stronger intensity of "high" experience.[4]
See also[edit]
References[edit]
- ^ a b Kraemer T, Paul LD (August 2007). "Bioanalytical procedures for determination of drugs of abuse in blood". Analytical and Bioanalytical Chemistry. 388 (7): 1415–35. doi:10.1007/s00216-007-1271-6. PMID 17468860. S2CID 32917584.
- ^ a b Huestis MA (2005). "Pharmacokinetics and metabolism of the plant cannabinoids, delta9-tetrahydrocannabinol, cannabidiol and cannabinol". Handbook of Experimental Pharmacology. 168 (168): 657–90. doi:10.1007/3-540-26573-2_23. ISBN 3-540-22565-X. PMID 16596792.
- ^ Lemberger, Louis, et. al "Comparative Pharmacology of Δ9-Tetrahydrocannabinol and its Metabolite, 11-OH-Δ9-Tetrahydrocannabinol" J Clin Invest (1973 Oct 52(10): 2411-2417
- ^ Wiley, Jenny L., et. al "Sex, species and age: Effects of rodent demographics on the pharmacology of ∆ 9-tetrahydrocanabinol" Prog Neuropsychopharmacol Biol Psychiatry (2021 Mar 2) 106:110064