11S globulin family

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11S globulin family is a family of globulin proteins chiefly found in seeds of legumes (legumin-like),[1] along with 7S family, often found in a protein fraction within an protein isolate. They are used as storage of important nutrients for plant growth, and therefore hardy enough to pass through the human digestive system unscathed. One common example of an 11S globulin includes glycinin derived from soy.


The term 11S refers to the sedimentation coefficient, with a range of 10.5–13 versus the vicilin-like globulins (7S family) with coefficients of 7.0–9.0[2]


It is characterized by a hexamer (with hexagonal shape). Several residues are conserved among 11S family. Like other globulins, they are not completely digested and broken into amino acids and have the potential to bind to various proteins in the body and can exert effects independent of their amino acids constituents, even after consumption.[3] They tend to have high emulsifying effects.[1]


  1. ^ a b "Pulse Proteins" (PDF). Pulsecanada.com. Archived from the original (PDF) on 2017-03-05. Retrieved 2017-02-26.
  2. ^ Michael C. Lawrence (1999). "Structural Relationships of 7S and 11S Globulins". Structural Relationships of 7S and 11S Globulins - Springer. pp. 517–541. doi:10.1007/978-94-011-4431-5_22. ISBN 978-94-010-5904-6.
  3. ^ Motoyasu Adachi; Jiro Kanamori; Taro Masuda; Kazuhiro Yagasaki; Keisuke Kitamura; Bunzo Mikami; Shigeru Utsumi (2003). "Crystal structure of soybean 11S globulin : Glycinin A3B4 homohexamer" (PDF). Proceedings of the National Academy of Sciences. 100 (12): 7395–7400. doi:10.1073/pnas.0832158100. PMC 165886. PMID 12771376. Retrieved 2017-02-26.

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