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Year 1450 (MCDL) was a common year starting on Thursday (link will display the full calendar) of the Julian calendar.
- February 7 – John de la Pole, 2nd Duke of Suffolk, marries Lady Margaret Beaufort.
- February 26 – Francesco Sforza enters Milan after a siege, becoming Duke of the city-state and, founding a dynasty that will rule Milan for a century.
- March – French troops under Guy de Richemont besiege the English commander in France, Edmund Beaufort, 1st Duke of Somerset, in Caen.
- April 15 – Battle of Formigny: French troops under the Comte de Clermont defeat an English army under Sir Thomas Kyriel and Sir Matthew Gough, which was attempting to relieve Caen.
- May 8 – Jack Cade's Rebellion: Kentishmen revolt against King Henry VI of England.
- May 9 – Abdal-Latif Mirza, a Timurid dynasty monarch, is assassinated.
- May 13 – Charles VIII of Sweden, also serving as Carl I of Norway, is declared deposed from the latter throne, in favor of Christian I of Denmark.
- June 18 – Battle of Seven Oaks: Jack Cade's rebels are driven from London by loyal troops, bringing about the collapse of the rebellion.
- July 6 – Caen surrenders to the French.
- July 12 – Jack Cade is slain in a skirmish.
- August 12 – Cherbourg, the last English territory in Normandy, surrenders to the French.
- October 5 – Jews are expelled from Lower Bavaria, by order of Duke Ludwig IX.
- November 3 – The University of Barcelona is founded.
- November 23 – First Siege of Krujë: Albanian troops are victorious, forcing an Ottoman army of approximately 100,000 men to retreat from Albania.
- January 9 – Adam Moleyns, Bishop of Chichester
- February 9 – Agnès Sorel, mistress of Charles VII of France (b. 1421)
- April 8 – Sejong the Great of Joseon, ruler of Korea (b. 1397)
- May 2 – William de la Pole, 1st Duke of Suffolk, English military leader (born 1396)
- May 9 – 'Abd al-Latif, ruler of Transoxania
- July 2 – Ranuccio Farnese il Vecchio, Italian condottiero (b. c. 1390)
- July 4 – James Fiennes, 1st Baron Saye and Sele
- July 18 – Francis I, Duke of Brittany (b. 1414)
- July 26 – Cecily Neville, Duchess of Warwick (b. 1424)
- August 15 – Alberto da Sarteano, Italian Franciscan friar and papal legate (b. 1385)
- August 27 – Reginald West, 6th Baron De La Warr, English politician (b. 1395)
- August 31 – Isabella of Navarre, Countess of Armagnac (b. 1395)
- September 16 – Louis Aleman, French cardinal
- September 22 – William Tresham, English politician
- October 1 – Leonello d'Este, Marquis of Ferrara, Italian noble (b. 1407)
- November 3 – Paola Colonna, Lady of Piombino (b. c. 1378)
- November 5 – John IV, Count of Armagnac (b. 1396)