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|1466 by topic|
|Arts and science|
|Birth and death categories|
|Births – Deaths|
|Establishments and disestablishments categories|
|Establishments – Disestablishments|
|Art and literature|
|1466 in poetry|
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- The Chimú Empire is conquered by troops of the Inca.
- The Mentelin Bible, the first printed German language Bible, is produced.
- Louis XI of France introduces silk weaving to Lyon.
- The Kingdom of Georgia collapses into anarchy, and fragments into rival states of Kartli, Kakheti, Imereti, Samtskhe-Saatabago and a number of principalities; this breakup is finalised in 1490, when Constantine II of Georgia has to recognize his rival monarchies.
- The 2nd largest bell of St. Peter's Church in Fritzlar is founded, by Meister Goswin aus Fritzlar.
- February 11 – Elizabeth of York, queen of Henry VII of England (d. 1503)
- May 22 – Marino Sanuto the Younger, Italian historian (d. 1536)
- June 18 – Ottaviano Petrucci, Italian music printer (d. 1539)
- July 5 – Giovanni Sforza, Italian noble (d. 1510)
- August 10 – Francesco II Gonzaga, Marquess of Mantua (d. 1519)
- September 9 – Ashikaga Yoshitane, Japanese shogun (d. 1523)
- October 28 – Erasmus, Dutch philosopher (d. 1536)
- November 16 – Francesco Cattani da Diacceto, Florentine philosopher (d. 1522)
- November 26 – Edward Hastings, 2nd Baron Hastings, English noble (d. 1506)
- November 30 – Andrea Doria, Genoese condottiero and admiral (d. 1560)
- February 23 – Girishawardhana Dyah Suryawikrama, 9th Maharaja of Majapahit
- March 6 – Alvise Loredan, Venetian admiral and statesman (b. 1393)
- March 8 – Francesco I Sforza, Duke of Milan (b. 1401)
- August – Hacı I Giray, first ruler of the Crimean Khanate
- October 30 – Johann Fust, German printer (b. c. 1400)
- December 13 – Donatello, Italian artist (b. 1386)
- date unknown