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Year 1483 (MCDLXXXIII) was a common year starting on Wednesday (link will display the full calendar) of the Julian calendar).
- January 1 – Jews are expelled from Andalusia.
- February 11 – Creation of the General Council of Inquisition in Spain.
- April 9 – Edward V becomes King of England.
- April 29 – Gran Canaria, the main of the Canary Islands is conquered by the Kingdom of Castile, a very important step in the expansion of Spain.
- April 30 – Pluto moves inside Neptune's orbit until July 23, 1503, according to modern orbital calculations.
- April – King Edward V of England and his younger brother Richard, Duke of York reside in the Tower of London. Later this year, rumors of their murders start circulating. By December the rumors have reached France. This is the beginning of the mystery concerning the fates of the two Princes in the Tower.
- June 13 – William Hastings, 1st Baron Hastings, is executed, in the first recorded execution at the Tower of London.
- June 20 – The powerful Fernando II, Duke of Braganza is executed in Portugal, followed by more than 80 other noblemen, for his plot against the Royal crown.
- June 25 – Before his coronation, King Edward V of England is deposed by his uncle, Richard, Duke of Gloucester, who becomes King as Richard III of England.
- July 6 – Richard III is crowned king of England at Westminster Abbey.
- July 20 – John of Denmark is crowned King of Norway.
- August 9 – The Sistine Chapel opens in the Apostolic Palace in Rome.
- September 3 – The Princes in the Tower, uncrowned 12-year-old Edward V of England and his 10-year-old brother, Richard, Duke of York, are perhaps murdered this night in the Tower of London.
- October – A rebellion by the Duke of Buckingham is crushed by Richard III of England.
- January 12 – Henry III of Nassau-Breda, Baron of Breda (d. 1538)
- February 14 – Zahir al-Din Mohammed Babur Shah, founder of the Moghul dynasty (d. 1530)
- March 6 – Francesco Guicciardini, Italian historian and statesman (d. 1540)
- April 6 – Raphael, Italian painter and architect (d. 1520)
- April 19 – Paolo Giovio, Italian bishop (d. 1552)
- July 20 – Wang Gen, Chinese philosopher (d. 1541)
- September 3 – Eric II, Duke of Mecklenburg (d. 1508)
- October 16 – Gasparo Contarini, Italian diplomat and cardinal (d. 1542)
- October 26 – Hans Buchner, German Renaissance composer (d. 1538)
- November 10 – Martin Luther, German monk and Protestant reformer (d. 1546)
- November 16 – Elisabeth of the Palatinate, Landgravine of Hesse, German noble (d. 1522)
- December 3 – Nicolaus von Amsdorf, German theologian and Protestant reformer (d. 1565)
- date unknown