The 15th century in North American History provides a timeline of events occurring within the North American continent from 1401 CE to 1500 CE in the Gregorian calendar. This time period (from 1000 BCE–present) is known as the Post-archaic period (Post-archaic stage). Although this timeline segment may include some European or other world events that profoundly influenced later American life, it focuses on developments within Native American communities. The archaeological records supplements indigenous recorded and oral history.
1493: Columbus returns to Spain from his first voyage and sets out again on the second of four voyages of exploration and attempted colonization around the Caribbean Sea. Columbus's second expedition includes 1000 settlers and many domesticated European horses, cattle, and pigs, marking the beginning of the Columbian exchange.