The 15th century in North American history provides a timeline of events occurring within the North American continent from 1401 CE to 1500 CE in the Gregorian calendar. This time period (from 1000 BCE–present) is known as the Post-archaic period (Post-archaic stage). Although this timeline segment may include some European or other world events that profoundly influenced later American life, it focuses on developments within Native American communities. The archaeological records supplements indigenous recorded and oral history.
1493: Columbus returns to Spain, setting sail again for the West Indies with one thousand settlers and many domesticated European horses, cattle, and pigs. This exchange of goods marks the beginning of the Columbian exchange.
1497: Italian navigator John Cabot sails from England to Newfoundland.
1499: Italian navigator Amerigo Vespucci sails to northern South America and recognizes the New World as a new continent.