1612 in science
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- The first description of the Andromeda Galaxy based on observations by telescope is given by Simon Marius.
- December 28 – Galileo observes the planet Neptune for the first time when it is in conjunction with Jupiter, but mistakenly catalogues it as a fixed star because of its extremely slow motion along the ecliptic, and it will not be properly identified until 1846.
- February – John Gerard, English herbalist (born c. 1545)
- February 12
- November 20 – Sir John Harington, English inventor (born 1561)
- Jacques de Cahaignes, French physician (born 1548)