1623 in science
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- Apple orchard at Grönsö Manor in Sweden planted; it will still be productive into the 21st century.
- Wilhelm Schickard draws a calculating clock on a letter to Kepler. This will be the first of five unsuccessful attempts at designing a direct entry calculating clock in the 17th century (including the designs of Tito Burattini, Samuel Morland and René Grillet).
- June 19 – Blaise Pascal, French mathematician and physicist (died 1662)
- October 9 – Ferdinand Verbiest, Flemish Jesuit Sinologist and astronomer (died 1688)
- probable date – Margaret Lucas, later Margaret Cavendish, Duchess of Newcastle-upon-Tyne, English natural philosopher (died 1673)
- 12 July – Elizabeth Walker, English pharmacist (born 1690)
- Michiel Coignet, Flemish engineer, cosmographer, mathematician and scientific instrument-maker (born 1549)
- Ferrand, Jacques. Maladie d'amour, ou Mélancolie érotique.