1653 in science
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- Jan van Kessel paints a series of pictures of insects and fruit.
- Blaise Pascal publishes his Traité du triangle arithmétique in which he describes a convenient tabular presentation for binomial coefficients, now called Pascal's triangle.
- Blaise Pascal publishes his Treatise on the Equilibrium of Liquids in which he explains his law of pressure.
- January 16 – Johann Conrad Brunner, Swiss anatomist (died 1727)
- March 24 – Joseph Sauveur, French mathematician and acoustician (died 1716)