17-Dimethylaminoethylamino-17-demethoxygeldanamycin

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17-Dimethylaminoethylamino-17-demethoxygeldanamycin
17-(dimethylaminoethylamino)-17-demethoxygeldanamycin.png
Names
IUPAC name
[(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-21-(2-dimethylaminoethylamino)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
Other names
17-DMAG; Alvespimycin
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
Properties
C32H48N4O8
Molar mass 616.76 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

17-Dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) is a chemical compound which is a semi-synthetic derivative of the antibiotic geldanamycin.[1][2] It is being studied for the possibility of treating cancer.[3]

References[edit]

  1. ^ WO application 2002079167, Snader, Kenneth M.; Vishnuvajjala, B. Rao; Hollingshead, Melinda G.; Sausville, Edward A., "Preparation of geldanamycin derivatives for the treatment of cancer", published 2002 
  2. ^ Rastelli, Giulio; Tian, Zong-Qiang; Wang, Zhan; Myles, David; Liu, Yaoquan (2005). "Structure-based design of 7-carbamate analogs of geldanamycin". Bioorganic & Medicinal Chemistry Letters. 15 (22): 5016–5021. PMID 16165354. doi:10.1016/j.bmcl.2005.08.013. 
  3. ^ Sausville, E. A.; Tomaszewski, J. E.; Ivy, P. (2003). "Clinical development of 17-allylamino, 17-demethoxygeldanamycin". Curr. Cancer Drug Targets. 3 (5): 377–83. PMID 14529389. doi:10.2174/1568009033481831.