April 15 – On Opening Day, Red Ames of the New York Giants allowed no hits through nine innings. In the 10th inning he gave up a single with one out. The Giants eventually fell to the Brooklyn Superbas, 3–0, in 13 innings. In total, Ames allowed a total of seven hits.
November 26 – The Philadelphia Phillies are sold for $350,000 to a group headed by sportswriter Horace Fogel. Because of his dual roles, Fogel will become the only executive barred from a league meeting.
January 2 – Paddy Quinn, 59, catcher/outfielder for the Kekiongas/Western/Dark Blues/White Stockings National Association teams from 1871 to 1877.
January 14 – Togie Pittinger, 37, pitcher who posted a 115–113 record and a 3.10 ERA in eight seasons with the Boston Beaneaters (1900–1904) and Philadelphia Phillies (1905–1907).
January 19 – Dennis Casey, 50,center fielder for the Wilmington Quicksteps (1884) and Baltimore Orioles (1884–1885).
February 4 – John Clarkson, 47, pitcher for Chicago, Boston and Cleveland who won over 325 games, then a National League record with six 30-win seasons, including 53 and a no-hitter (1885); (1885); leading the league for the most innings pitched four times, and in strikeouts, games and complete games three times each.
February 17 – Jim Burns, [?], outfielder for the Kansas City Cowboys (1888) and Washington Statesmen (1891) of the American Association.
February 20 – John Hatfield, 61, left fielder/infielder for the New York Mutuals.
March 15 – Howard Wall, 54, shortstop who played one game for the 1873 Washington Blue Legs.
April 29 – Doc Powers, 38, who was catching in the first game played in Shibe Park in Philadelphia when he crashed into a wall going after a pop fly. He remained in the game, but suffered from internal injuries that took his life two weeks later, when gangrene set in after three operations. He was the first major leaguer to die from injuries sustained during a game.
June 20 – Rudy Kemmler, 49?, catcher for eight seasons from 1879 to 1889.
July 5 – Frank Selee, 49, manager who guided Boston to five National League pennants (1891–93, 1895–96) and later built foundation of championship Cubs teams, collecting a .607 winning percentage –highest among managers of 1500 games–, and 1284 victories to rank second all-time upon retirement.
September 5 – Bill Popp, 32, pitcher who posted a 2–6 record in nine games for the 1902 St. Louis Cardinals.
September 17 – Herman Long, 43, shortstop for the Boston Beaneaters who batted .300 four times, led NL in runs in 1893 and home runs in 1900; set career marks for putouts and total chances, led league in double plays three times and in putouts and fielding average twice each.
September 20 – Joe Wright, 40, center fielder for the Louisville Colonels (1895) and Pittsburg Pirates (1896).
October 13 – Sleeper Sullivan, 50, Irish catcher who played for the Brown Stockings/Bisons/Browns/Maroons/Eclipse teams from 1881 to 1884.
October 26 – Frank Siffell, German catcher for the Philadelphia Athletics of the American Association (1884–1885).
October 29 – John Lyston, 42, pitcher for the Columbus Solons (1891) and Cleveland Spiders (1894).
November 5 – Walt Kinzie, 51, shortstop for the Wolverines, White Stockings and Browns from 1882 to 1884.
December 8 – Buffalo Bill Hogg, 27, pitcher who posted a 37–50 record in four seasons with the New York Highlanders of the American League (1905–1908).
December 21 – Kid Keenan, 40, pitcher for the 1891 Cincinnati Kelly's Killers of the American Association.
December 22 – Jimmy Sebring, 27, outfielder for the Pittsburg, Cincinnati, Brooklyn and Washington teams from 1902 to 1909, who became the first player in World Series history to hit a home run (1903).
December 23 – Harry H. Gilbert, 41, second baseman for the 1890 Pittsburg Alleghenys of the National League..