1922 in Wales
- Prince of Wales - Edward
- Princess of Wales – vacant
- Archbishop of Wales – Alfred George Edwards, Bishop of St Asaph
- Archdruid of the National Eisteddfod of Wales – Dyfed
- 1 January - The Rhondda and Swansea Bay Railway is incorporated into the Great Western Railway.
- February - The last fighting ship completes fitting out and commissioning at Pembroke Dock, Royal Navy light cruiser HMS Capetown.
- 26 April - The last ship is launched from Pembroke Dock, Royal Fleet Auxiliary tanker Oleander.
- 11 October - Leila Megane makes the first complete recording of Sir Edward Elgar's Sea Pictures, with Elgar himself conducting.
- 18 October - In a by-election at Newport, caused by the death of Liberal MP Lewis Haslam, Reginald Clarry wins the seat for the Conservatives.
- 22 October - David Lloyd George is replaced by Bonar Law as Prime Minister of the United Kingdom, after the Conservatives leave the Coalition Government.
- The Welsh youth organisation Urdd Gobaith Cymru is founded by Ifan ab Owen Edwards.
Arts and literature
- Wilfred Mitford Davies sets up the first Welsh children's book publisher, Cymru'r Plant.
- The Gregynog Press is established by the sisters Margaret and Gwendoline Davies (granddaughters of Victorian industrialist David Davies) of Gregynog Hall.
- The University of Wales Press is established.
- National Eisteddfod of Wales (held in Ammanford)
- National Eisteddfod of Wales: Chair - J. Lloyd-Jones
- National Eisteddfod of Wales: Crown - Robert Beynon
- D. Ambrose Jones - Llenyddiaeth a Llenorion Cymreig y bedwaredd ganrif ar bymtheg
- Henry Jones - A Faith that Enquires
- Arthur Machen - The Secret Glory
- Walford Davies is knighted for his services to music.
- The Last King of Wales, starring Charles Ashton
- Lyn Harding makes an early screen appearance in When Knighthood Was in Flower.
- Ivor Novello stars in The Bohemian Girl
- Rugby union - Wales wins the Five Nations championship.
- Football (soccer)
- 16 February – Sir Geraint Evans, opera singer (d. 1992)
- 16 April
- 21 April – Allan Watkins, England Test cricketer (d. 2011)
- 11 June – Tom Cole, Welsh-American racing driver (d. 1953)
- 18 July – Ray Cale, dual code international rugby player (d. 2006)
- 20 July – Ruth Bidgood (née Jones), poet
- 31 October – Talfryn Thomas, comedy actor (d. 1982)
- 29 January – George Owen, footballer, 56
- 4 February – Sir Henry Jones, philosopher, 69
- 22 April – W. Llewelyn Williams, lawyer and historian, 55
- 3 May – Dick Kedzlie, Wales international rugby player, 59
- 14 May – William Abraham ("Mabon"), politician, 79
- 16 May – Thomas Powel, Celtic scholar, 76/77
- 2 June – Sir John David Rees, politician, 67
- 18 June – John Ward, archaeologist, National Museum of Wales, 65/66
- 20 June – John Williams, politician, 60
- 8 July – James Bevan Edwards, army officer and politician, 86
- 6 August – Thomas Pryce-Jenkins, Wales international rugby player, 60
- 12 August – Arthur Griffith, Irish-born nationalist politician of Welsh descent, 50
- 22 August – John Bryn Edwards, ironmaster, 33
- 12 September – George Rowles, Wales international rugby player, 55/56
- 28 September – Charlie Newman, Wales rugby union captain, 65
- 25 December – Percy Jones, former world boxing champion, 29
- 27 December – Thomas William Rhys Davids, Pali scholar, 79