October 4 – For the second year in a row, every game of the World Series is played at the Polo Grounds in New York City since it houses both the Giants and Yankees. The Giants score three in the eighth inning to take game one, 3–2.
March 11 – Joe Gerhardt, 67, second baseman for several teams from 1873 to 1891, who led the National League in assists twice and in double plays three times.
March 14 – Danny Hoffman, 42, center fielder for the Athletics, Highlanders and Browns from 1903 through 1911, who led the American League in stolen bases during the 1905 season.
March 26 – Count Gedney, 72, left fielder who played from 1872 through 1875 for the Mutuals, Athletics, Eckfords and Haymakers of the National Association.
April 1 – Leech Maskrey, 68, left fielder for the Louisville Eclipse/Colonels and the Cincinnati Red Stockings from 1882 to 1886.
April 1 – Harry Smith, 31, catcher for the New York Giants, Brooklyn Tip-Tops and Cincinnati Reds between 1914 and 1918.
April 14 – Cap Anson, 69, Hall of Fame first baseman for the Chicago White Stockings who was the 19th century's most prolific hitter, setting career records for games, hits, runs, doubles and RBI; batted .333 lifetime, winning three batting titles, also ranked sixth all-time in home runs upon retirement; managed Chicago to five pennants (1880–82, 1885–86), 1296 career victories were record until 1907; among first managers to use pitching rotation, and first to organize spring training.
May 19 – Bob Reach, 78, National Association shortstop who played from 1872 to 1873 for the Olympics and Blue Legs teams based in Washington, D.C..
May 22 – Bill Daley, 53, pitcher for three seasons; one for the Boston Beaneaters, and two for the Boston Reds.
May 24 – Charlie Frank, 61, outfielder for the St. Louis Browns from 1893 to 1894.
May 25 – Charlie Gessner, 58, pitcher for the 1886 Philadelphia Athletics of the American Association.
May 31 – John Coleman, 59, pitcher/outfielder for the Pittsburgh Alleghenys and the Quakers/Athletics Philadelphia teams between 1883 and 1890, who led all National League pitchers in starts, complete games and innings pitched during the 1883 season.
June 12 – Chief Johnson, 36, pitcher who played from 1913 to 1914 for the Cincinnati Reds of the National League and the Kansas City Packers of the Federal League.
June 24 – Dan O'Leary, 65, outfielder from 1879–1884, player-manager for the 1884 Cincinnati Outlaw Reds of the Union Association.
June 28 – Dick Lowe, 68, catcher for the 1884 Detroit Wolverines of the National League.
July 4 – John Pickett, 56, second baseman/outfielder for three seasons from 1889 to 1892.
July 10 – Harvey Bailey, 45, pitcher who played for the Boston Beaneaters of the National League in 1899 and 1900.
July 15 – Charlie Kuhns, 46, National League infielder for the Pittsburgh Pirates (1897) and the Boston Beaneaters (1899).
July 20 – Dick Pierson, 64, first baseman for the 1885 New York Metropolitans of the American Association.
July 27 – Nig Cuppy, 53, pitcher who won 24 or more games four times for the Cleveland Spiders.
August 5 – Tommy McCarthy, 59, Hall of Fame outfielder for the St. Louis and Boston teams who batted .300 four times and pioneered several strategies; defensive standout led American Association in assists and steals once each.
August 12 – Sam King, 70, first baseman for the 1884 Washington Nationals of the American Association.
November 1 – Billy Goeckel, 51, first baseman for the 1899 Philadelphia Phillies.
November 4 – John Houseman, 52, Dutch infielder/outfielder who played with the Chicago Cubs in 1894 and for the St. Louis Cardinals in 1897.
November 6 – Morgan G. Bulkeley, 84, executive who served as the National League's first president in 1876, also as president of Hartford club; later a governor of Connecticut and U.S. Senator.
November 7 – Sam Thompson, 62, Hall of Fame right fielder for Detroit and Philadelphia who batted .331 lifetime and won 1887 batting title; led National League in hits three times, home runs and doubles twice each; until 1921, held record of 166 RBI (1887) and ranked second in career home runs; his .505 career slugging average was second highest of 19th century.
November 11 – Dave Pierson, 67, catcher/outfielder for the 1876 Cincinnati Reds.
November 14 – Doc Oberlander, 58, pitcher for the 1888 Cleveland Blues of the American Association.
November 18 – Len Lovett, 70, outfielder for the Elizabeth Resolutes (1873) and Philadelphia Centennials (1875) National Association teams.
November 23 – Sandy McDermott, 66, second baseman for the 1885 Baltimore Orioles of the American Association.
November 27 – Austin McHenry, 27, dies from a brain tumor after hitting .350 with 17 home runs and 110 RBI for the 1921 St. Louis Cardinals, who became ill during the 1922 season and was hitting .303 when forced to quit.
December 1 – Jim Snyder, 75, catcher/shortstop for the Brooklyn Eckfords of the National Association between 1870 and 1872.
December 22 – Dad Meek, 55, catcher who played from 1889 through 1890 for the St. Louis Browns of the American Association.
December 25 – Wes Fisler, 81, infielder/outfielder who hit .310 for the Philadelphia Athletics from 1871 to 1876, and a member of the 1871 National Association champion team.