September 25 – The Philadelphia Phillies snap a twelve-game losing streak with a 5-2 victory over the Chicago Cubs. It is Philadelphia's second twelve-game losing streak of the season (July 7 to July 20).
October 4 – A seventh inning solo home run by Jim Bottomley is one of only three hits for the St. Louis Cardinals as the New York Yankees take game one of the 1928 World Series, 4-1.
October 5 – Lou Gehrig has five RBIs, including a first inning three run home run to lead the New York Yankees to a 9-3 victory in game two of the World Series.
October 7 – Lou Gehrig hits two home runs, including an inside the park home run in the fourth in the Yankees' 7-3 victory in game three of the World Series.
October 9 – The New York Yankees defeat the St. Louis Cardinals, 7–3, in Game four of the World Series to win their third World Championship title. Babe Ruth hits three home runs in Game four. This is the second time in three years Ruth hits three home runs in a Series game.
December 1 – National League President John Heydler becomes the first person to propose a baseball rule change calling for a 10th man, or a designated hitter, to bat in place of the pitcher. The NL will vote in favor of the proposal, but the American League will turn it down.
January 2 – Hunkey Hines, 60, right fielder in two games for the 1895 Brooklyn Grooms of the National League.
January 14 – Al Reach, 87, Anglo-American sportsman who as second baseman became the first professional player in 1865; batted .353 for 1871 champion Athletics in first season of National Association; co-founder of the Phillies, serving as team president from 1883–1902, later part owner of Athletics; publisher of annual baseball guides beginning in 1883, and also was responsible for the invention of the cork-center baseball.
January 16 – Claude Rossman, 46, American League first baseman/right fielder who played with the Cleveland Naps, Detroit Tigers and St. Louis Browns in parts of five seasons spanning 1904-09.
January 28 – Jake Thielman, 48, pitcher for the St. Louis Browns, Cleveland Naps and Boston Red Sox of the American League between 1905 and 1908.
January 30 – Jim Foran, 80, first baseman for the 1871 Fort Wayne Kekiongas of the National Association.
February [?] – Pablo Mesa, 30, Negro League outfielder/pitcher for the Cuban Stars (East) from 1921 through 1927.
February 1 – Hughie Jennings, 58, Hall of Fame shortstop, most notably for the Baltimore Orioles of the National League, who batted .311 lifetime but had career shortened by numerous beanings, who as team captain was runnerup in 1896 batting race with .401 mark, managed the Detroit Tigers to consecutive pennants from 1907 to 1909, and later coached for the New York Giants.
February 4 – Bill McCarthy, 41, backup catcher for the 1905 Boston Beaneaters and 1907 Cincinnati Reds of the National League.
February 9 – Bill Farmer, 63, Irish catcher/outfielder for the NL Pittsburgh Alleghenys and the AA Philadelphia Athletics in 1888.
February 13 – Pete Daniels, 63, pitcher for the 1890 Pittsburgh Alleghenys and 1898 St. Louis Browns of the National League.
February 23 – Jack Ridgway, 39, pitcher for the 1914 Baltimore Terrapins of the Federal League.
February 27 – Walt Schulz, 27, pitcher for the 1920 St. Louis Cardinals of the National League.
March 5 – Mart McQuaid, 66, backup second baseman/outfielder for the 1891 St. Louis Browns of the American Association and the 1898 Washington Senators of the National League.
March 13 – Bobby Wheelock, 63, shortstop/outfielder for the NL Boston Beaneaters and the AA Columbus Solons in parts of three seasons spanning 1887-91.
March 14 – Nat Hudson, 69, pitcher for the St. Louis Browns of the American Association from 1886 through 1889, who helped his team win the 1886 World Series over the National League's Chicago White Stockings, and posted a 25-10 record with a 2.54 ERA and a top-league .714 winning percentage in 1888.
March 19 – Tom Lovett, 64, pitcher for six seasons between 1885 and 1894, mainly with the NL Brooklyn Bridegrooms, who collected 30 wins in 1890 and hurled a no-hitter against the New York Giants in 1891.
March 23 – Jake Kafora, 39, backup catcher for the NL Pittsburgh Pirates from 1913 to 1914.
March 25 – Homer Smoot, 50, center fielder who batted a .290 average in 680 games with the St. Louis Cardinals and Cincinnati Reds from 1902 to 1906, and led all National League outfielders with 284 putouts in 1902.
April 1 – Marr Phillips, 70, shortstop who played in parts of three seasons spanning 1884-90 with the Indianapolis Hoosiers, Pittsburgh Alleghenys and Rochester Broncos of the American Association, and for the Detroit Wolverines of the National League.
April 6 – Ike McAuley, 36, National League shortstop for the Pittsburgh Pirates (1914–16), St. Louis Cardinals (1917) and Chicago Cubs (1925).
April 19 – Harry McCaffery, 69, outfield/infield utility for the St. Louis Brown Stockings/Browns and Louisville Eclipse of the American Association from 1882 to 1883.
April 23 – Joe Miller, 67, shortstop for the 1884 Toledo Blue Stockings and the 1885 Louisville Colonels of the American Association.
April 24 – Harry Berthrong, 84, infield/outfield utility and catcher in 17 games with the 1871 Washington Olympics of the National Association.
April 26 – Zeke Wilson, 58, pitcher from 1895 through 1899 for the Boston Beaneaters, Cleveland Spiders and St. Louis Perfectos of the National League.
May 1 – Bull Smith, 47, outfielder for the Pittsburgh Pirates, Chicago Cubs and Washington Senators between the 1904 and 1911 seasons.
May 6 – Sam Wright, 79, younger brother of Hall of Famers Harry and George Wright, who played at shortstop for the New Haven Elm Citys, Boston Red Stockings and Cincinnati Reds in parts of four seasons spanning 1875-81.
May 10 – Ed Stein, 58, pitcher who played from 1890 through 1898 for the Chicago Colts and Brooklyn Grooms/Bridegrooms of the National League.
May 24 – Billy Smith, 67, pitcher for the 1886 Detroit Wolverines of the National League.
May 25 – Max Fiske, 39, pitcher for the 1914 Chicago Chi-Feds of the outlaw Federal League.
May 31 – Grant Briggs, 63, part-time catcher/outfielder in 110 games with the Syracuse Stars, Louisville Colonels and St. Louis Browns between 1890 and 1895.
June 1 – Charlie Jordan, 56, pitcher for the 1896 Philadelphia Phillies of the National League.
June 13 – Chuck Corgan, 25, backup middle infielder for the National League Brooklyn Robins in the 1925 and 1927 seasons.
June 14 – Con Daily, 63, catcher who also played all infield and outfield positions for seven teams in two different leagues, mainly for the Brooklyn Grooms of the National League, in a 12-year career that spanned from 1895 to 1996.
June 19 – Jake Weimer, 54, National League pitcher who posted a 97-69 record from 1903 to 1909 for the Cubs, Reds and New York Giants, including three 20-win seasons and a 2.23 career ERA in 143 complete games.
June 23 – Malachi Kittridge, 58, catcher for the Louisville Colonels, Boston Beaneaters, Washington Senators and Cleveland Naps between 1890 and 1906.
June 24 – Frank Cox, 70, shortstop in 26 games with the 1884 Detroit Wolverines of the National League.
July 2 – Pete Hotaling, 71, center fielder for six different teams in two leagues, primarily for the Cleveland Blues of the National League, during parts of nine seasons spanning 1879-88.
July 15 – Al Sauter, 59, third baseman for the 1890 for the Philadelphia Athletics of the American Association.
July 18 – Ed Killian, 51, pitcher who posted a 103-78 record and a 2.38 ERA in 214 games from 1903 to 1910, collecting two 20-win seasons, allowing nine home runs in 1600 career innings (none from 1903–07), while clinching the 1907 American League pennant for the Detroit Tigers with two wins in a doubleheader.
July 30 – Charlie Becker, 37, pitcher from 1911–1912 for the Washington Senators of the American League.
August 21 – Joe Mulvey, 69, third baseman who played from 1883 to 1895 for seven teams in three different league, including four Philadelphia franchises, collecting 1059 hits in 4063 at-bats for a .261 average in 987 games.
August 25 – Snake Wiltse, 56, pitcher/first baseman/outfielder for the Pittsburgh Pirates, Philadelphia Athletics, Baltimore Orioles and New York Highlanders from 1901 through 1903, who posted a 29-31 record and a 4.59 ERA in 68 games pitched, while batting a .278 average with a .398 of slugging in 86 games.
September 9 – Urban Shocker, 38, American League pitcher who posted a 187-117 record and a 3.17 ERA in 187 games with the St. Louis Browns and New York Yankees from 1916–1928, leading the league in wins (27) in 1921 and for the most strikeouts (149) in 1922, ending his career with four 20-win seasons and a 1.50 SO/BB ratio in 2681 innings.
October 11 – Frank Smith, 70, Canadian catcher for the 1884 Pittsburgh Alleghenys of the National League.
October 14 – Billy Milligan, 60, pitcher for the 1901 Philadelphia Athletics (AL) and the 1904 New York Giants (NL).
October 14 – Bill Stuart, 55, middle infielder who played in part of two seasons for the Pittsburgh Pirates (1895) and New York Giants (1899) of the National League.
October 15 – Pony Sager, 80, shortstop/left fielder in eight games for the 1871 Rockford Forest Citys of the National Association.
October 22 – Jack Dunn, 56, major league pitcher/third baseman for five teams from 1897 to 1904, who became owner and manager of minor league Baltimore Orioles in 1907, where he developed stars as Babe Ruth and Lefty Grove, while winning seven consecutive pennants from 1919 through 1925, ending his career as the second winningest manager in minor league history.
October 27 – Billy West, 75, National League second baseman who played for the 1874 Brooklyn Atlantics and the 1876 New York Mutuals.
October 31 – José Méndez, 41, generally regarded as one of the greatest players in Cuban baseball history, who was a star pitcher in the Negro Leagues, primarily with the All Nations team and the Kansas City Monarchs, while managing the Monarchs from 1920 to 1926, leading them to the first ever Negro League World Series title in 1924.
November 4 – Ed Kelly, 39, relief pitcher for the 1914 Boston Red Sox of the American League.
November 5 – George Treadway, 61, National League outfielder from 1893 through 1896 for the Baltimore Orioles, Brooklyn Grooms and Louisville Colonels, who posted a .285 average and a .432 of slugging in 328 career games.
November 6 – Bill Cooney, 45, relief pitcher from 1909 to 1910 for the Boston Doves of the National League.
November 11 – Oyster Burns, 64, right fielder for five teams between 1884 and 1895, primarily for the Brooklyn Bridegrooms, who led the National League in home runs (13) and RBI (128) in the 1887 season, while ending with a .300 batting average and a .445 slugging in 1188 career games.
November 14 – Herb Juul, 42, pitcher in one game for the 1911 Cincinnati Reds.
November 15 – Charlie Dorman, 30, backup catcher for the Chicago White Sox during the 1923 season.
November 18 – Jim Gilmore, 75, catcher for the 1875 Washington Nationals of the National League.
November 21 – Pete Lohman, 64, catcher for the 1891 Washington Statesmen of the American Association.
November 26 – Denny Clare, 75, middle infielder for the 1872 Brooklyn Atlantics of the National Association.
November 26 – Butts Wagner, 57, the older brother of Honus Wagner, who played at third base and outfield for the Washington Senators and the Brooklyn Bridegrooms during the 1898 season.
December 2 – Bill Hugues, 68, first baseman/outfielder and pitcher who played for the 1884 Washington Nationals of the Union Association and the 1885 Philadelphia Athletics of the American Association.
December 22 – Hugh Reid, 76, right fielder in one game for the 1874 Baltimore Canaries of the National Association.
December 27 – George Meister, 74, third baseman for the 1884 Toledo Blue Stockings of the American Association.
December 29 – Mort Scanlan, 67, first baseman for the 1890 New York Giants of the National League.