January 6 – New York Giants President Charles A. Stoneham dies of Bright's disease. He was the last surviving member of the trio that purchased the team in 1919. His son, Horace Stoneham, is elected the team's new president. Stoneham‚ 32‚ will remain president for the next 40 years before selling the team in 1976.
April 14 – Opening day, the New York Yankees are shut out, 1–0, by Bobo Newsom and the Washington Senators.
In St. Louis, the Cardinals' Eddie Morgan becomes the first to hit a pinch-hit home run in his first major league at bat. Morgan connects on the very first pitch he sees in the 7th inning. The Cubs win, 12-7.
In St. Louis‚ Roy Parmelee‚ former New York Giants pitcher‚ beats Carl Hubbell, 2–1, in a seventeen inning duel. The game is scoreless until the 12th when the Giants score a run‚ but the Cardinals match it in the bottom of the 12th. Parmelee allows just six hits in 17 innings‚ while Hubbell gives up 11.
May 3 – Joe DiMaggio makes his major league debut in left field in the New York Yankees' 14–5 victory over the St. Louis Browns. DiMaggio goes three-for-six- with a triple, an RBI and three runs scored.
May 10 – The New York Yankees defeat the Philadelphia Athletics, 7–2. With a loss by the Boston Red Sox to the Washington Senators, the Yankees take over first place in the American League. They remain in first place for the rest of the season, winning the pennant by 19.5 games over the Detroit Tigers.
May 24 – The New York Yankees defeat the Philadelphia Athletics 25–2. Second basemanTony Lazzeri has eleven RBIs in the game via two grand slams and a third home run and a triple. With his last blast, Lazzeri amassed seven home runs in four successive games to set a Major League record.
June 6 – St. Louis Cardinals second basemanStu Martin ties a major league record with eleven assists in the first game of a doubleheader with the New York Giants.
July 18 – The Chicago White Sox and Philadelphia Athletics set an American League record for the most combined runs scored by two teams in Chicago's 21–14 victory. ChiSox outfielderRip Radcliff ties an AL record with six hits in seven at-bats.
October 2 – A seven run third inning, highlighted by Tony Lazzeri's grand slam, carries the Yankees to an 18–4 victory in game two of the World Series.
October 3 – Frankie Crosetti's eighth inning RBI single carries the Yankees to a 2–1 victory over the Giants in game three of the World Series.
October 4 – The Yankees jump to an early 4–0 lead against Carl Hubbell, and win game four of the World Series, 5–2.
October 5 – Jo-Jo Moore leads off the tenth with a double, and comes around to score, as the New York Giants take game five of the World Series, 5–4.
October 6 – The New York Yankees defeat the New York Giants, 13–5, in Game 6 of the World Series to win their fifth World Championship title, four games to two. During the six games, the Yankees score 43 runs and collect 65 hits.
December 10 – In a three team trade, the Washington Senators send Earl Whitehill to the Cleveland Indians, Indians sent Thornton Lee to the Chicago White Sox, and the White Sox send Jack Salveson to the Senators.
February 3 - Andy Boswell, 62, pitcher who played for the Washington Senators and New York Giants of the National League during the 1895 season.
February 4 - Frank Jones, 77, shortstop and outfielder for the Detroit Wolverines in 1884.
February 5 - Fred Blank, 61, pitcher who played briefly for the Cincinnati Reds in 1894.
February 7 - Jimmy Dygert, 51, pitcher for the Philadelphia Athletics from 1905 to 1910, who pitched a combined no-hitter with Rube Waddell during the 1906 season.
February 9 - Trick McSorley, 83, who played in six different positions for the St. Louis Red Stockings, Toledo Blue Stockings, St. Louis Maroons, and St. Louis Browns in parts of four seasons spanning 1875–1886.
February 15 - Bill Grahame, 52, pitcher who played from 1908 through 1910 for the St. Louis Browns.
February 17 - Tom York, 85, left fielder who played 15 seasons from 1871 to 1885, most prominently for the Providence Grays, and also managed them the entire first season of the team's existence in 1878.
May 5 - Bill Anderson, 71, pitcher for the Louisville Colonels in the 1889 season.
May 5 - Lou Sylvester, 81, outfielder who played for the Cincinnati Outlaw Reds, Louisville Colonels, Cincinnati Red Stockings and St. Louis Browns in parts of three seasons spanning 1884–1887.
May 12 - Frank Zinn, 70, catcher for the 1888 Philadelphia Athletics.
May 19 - Sammy Curran, 61, pitcher for the Boston Beaneaters during the 1902 season.
May 22 - Kaiser Wilhelm, 62, pitcher for the Pittsburgh Pirates, Boston Beaneaters, Brooklyn Superbas, and Baltimore Terrapins during seven seasons from 1904–1915, and also a player/manager for the 1921 Philadelphia Phillies.
May 23 - Ted Lewis, 63, pitcher for the Boston Beaneaters and Boston Americans from 1896 to 1901, who led the National League with a .768 Win-Loss % in 1898, and also one of only three Welsh-born ballplayers in Major League history, along with Jimmy Austin and Peter Morris.
June 9 - Charlie Bartson, 71, pitcher who played for the Chicago Pirates of the Players' League during the 1890 season.
June 16 – Billy Shindle, 75, third baseman for the Detroit Wolverines, Baltimore Orioles, Philadelphia Athletics and Phillies, and Brooklyn Bridegrooms from 1886–98, also one of the first sluggers in the deadball era.
June 18 - Al Nichols, 84, third baseman for the Brooklyn Atlantics, New York Mutuals and Louisville Grays from 1875 to 1877, who is credited as the first player born in England to reach the major leagues.
June 21 - Ambrose Puttmann, 55, pitcher who played from 1903 through 1906 with the New York Highlanders and the St. Louis Cardinals.
September 8 - Bill Yerrick, 62, pitcher for the Boston Beaneaters of the National League in the 1895 and 1896 seasons.
September 9 - William Betts, 75, umpire who officiated in the National League from 1894 to 1899 and the American League in 1901 and 1903.
September 11 - Braggo Roth, 44, outfielder for the Chicago White Sox, Cleveland Indians, Philadelphia Athletics, Boston Red Sox, Washington Senators, and New York Yankees from 1914 through 1921, who led the American League in home runs in the 1915 season.
September 16 - Henry Lampe, 63, pitcher for the Boston Beaneaters in 1894 and the Philadelphia Phillies in 1895.
September 19 - Bill Hart, 71, National League pitcher who played with the Philadelphia Athletics, Brooklyn Grooms, Pittsburgh Pirates, St. Louis Browns, and Cleveland Blues in parts of seven seasons spanning 1886–1901.
October 4 - Hercules Burnett, 67, center fielder who played for the Louisville Colonels in the 1888 and 1895 seasons.
October 8 - Red Ames, 54, pitcher for the New York Giants, Cincinnati Reds, St. Louis Cardinals and Philadelphia Phillies from 1903 through 1919, who posted a career record of 183–167 wins with a 2.63 ERA and 1,702 strikeouts, and was a member of the World Champions Giants in 1904 and 1905.
October 16 - Dennis Fitzgerald, 71, English-born shortstop for the Philadelphia Athletics of the American Association in 1890.
October 19 - Jumping Jack Jones, 75, pitcher who played for the Detroit Wolverines and Philadelphia Athletics during the 1883 season.
October 20 - George Kelb, 66, pitcher for the 1898 Cleveland Spiders of the National League in 1898.
October 21 - Charlie Mason, outfielder who played with the Philadelphia Centennials, Washington Nationals, and Philadelphia Athletics in part of two seasons between 1875 and 1883.
October 22 - Fred Olmstead, 55, pitcher who played from 1908 through 1911 for the Chicago White Sox.
October 27 - Dave Black, 44, pitcher who played for the Chicago ChiFeds/Whales and Baltimore Terrapins of the Federal League from 1914 to 1915, and the Boston Red Sox in 1923.
October 30 - Jack Morrissey, 60, second baseman for the Cincinnati Reds from 1902 to 1903.
October 31 - Deacon McGuire, 72, catcher for 13 different teams over 26 seasons, who set a record number of seasons for a record number of teams, set career catching marks for defensive games, putouts, assists, caught stealing and stolen bases against, and was the first catcher to collect 300 doubles and hit .300 five times, before becoming a long time coach and manager.