The 1949–50 Serie C was the twelfth edition of Serie C, the third highest league in the Italian football league system.
To reduce the groups into an 18-team formula, additional relegations were added during the season. However, the plan was later partially postponed.
- ^ Renounced to play the promotion tie-breaker.
- ^ Relegated after tie-breaker (Luino-Pro Vercelli 1-0), but later readmitted for sport merits.
- ^ Relegated after tie-breakers: Luparense-Pro Gorizia 1-1; Pro Gorizia-Mestrina 1-1; Mestrina-Luparense 2-0
- ^ a b c Relegated and later readmitted to Serie C.
- ^ a b 1 point deducted.
- ^ Promoted after tie-breaker: Messina-Cosenza 1-1; repetition: 6-1