The 1963 NCAA Men's Division I Basketball Tournament involved 25 schools playing in single-elimination play to determine the national champion of men's NCAADivision Icollege basketball in the United States. It began on March 9, 1963, and ended with the championship game on March 23 in Louisville, Kentucky. A total of 29 games were played, including a third-place game in each region and a national third-place game.
In the Loyola vs. Mississippi State game at East Lansing, Michigan in a Mideast regional semifinal, Mississippi State, an all-white team, played despite protests from the governor and state police of Mississippi. Mississippi State overcame a state prohibition against playing integrated teams. Loyola beat Mississippi State and went on to the Mideast Region Championship game. In the National Championship game, Loyola started four African-Americans and Cincinnati started three, marking the first time that a majority of African-Americans participated in the championship game.
Loyola's first-round regional victory over Tennessee Tech, 111-42, continues to be a record margin of victory for an NCAA men's basketball tournament game.