Three players received first-team All-ACC honors from the Associated Press: fullback Brian Piccolo, quarterback John Mackovic, and end Richard Cameron. Piccolo was a unanimous selection for the all-conference team, and was also selected as a first-team All-American by Football News. He set three ACC records in 1964 with 1,044 rushing yards, 111 points scored, and 17 touchdowns. Piccolo also led the nation in 1964 in rushing yards, rushing touchdowns, and points scored. He was named the Atlantic Coast Conference (ACC) Player of the Year, yet went unselected in the both the AFL and NFL drafts. Mackovic led the Demon Deacons with 1,340 passing yards while completing 89 of 195 passes. Cameron caught 29 passes for 410 yards.
^"More Honors: FN releases 33-man team". The Freso Bee. 1964-11-24.referenced April 3, 2009.
^The Associated Press and Newspaper Enterprise Association selected Piccolo as a second-team All-American behind Gale Sayers, who would later be Piccolo's roommate with the Chicago Bears, as depicted in the film Brian's Song.