1980–81 Cypriot First Division
|European Cup||Omonia (1st round)|
|UEFA Cup||APOEL (1st round)|
|Cup Winners' Cup||Enosis (1st round; via Cypriot Cup)|
|Goals scored||450 (2.47 per match)|
|Top goalscorer||Sotiris Kaiafas
Fourteen teams participated in the 1980–81 Cypriot First Division. All teams played against each other twice, once at their home and once away. The team with the most points at the end of the season crowned champions. The last two teams were relegated to the 1981–82 Cypriot Second Division.
Teams received two points for a win, one point for a draw and zero points for a loss.
Changes from previous season
APOP Paphos and Evagoras Paphos were relegated from previous season and played in the 1980–81 Cypriot Second Division. They were replaced by the first team of the 1979–80 Cypriot Second Division, Nea Salamina.
Stadia and locations
|1||Omonia||26||16||6||4||56||21||35||38||Champions-1981–82 European Cup 1st Round.|
|2||APOEL||26||13||10||3||41||16||25||36||1981–82 UEFA Cup 1st Round.|
|4||Enosis Neon Paralimni||26||11||10||5||32||21||11||32||Cypriot Cup Finalist-1981–82 European Cup Winners' Cup 1st Round.1|
|13||Alki Larnaca||26||7||7||12||25||40||-15||21||Relegated to 1981–82 Cypriot Second Division.|
Points system: Won=2 points, Drawn=1 point, Lost=0 points
Rules for classification: 1) Points, 2) Goal differences, 3) Goal for
- Cypriot First Division
- 1980–81 Cypriot Cup
- List of top goalscorers in Cypriot First Division by season
- Cypriot football clubs in European competitions