Game 5 capped the series in fitting fashion, with seemingly endless surprises and excitement. The Astros jumped to an early lead in the first on a run-scoring double by José Cruz. Philadelphia bounced back to take the lead on a two-run single by Bob Boone in the second. The Astros saw Luis Pujols and Enos Cabell thrown out at the plate in the second and fifth, but finally broke through to tie the game 2-2 on an unearned run in the sixth, thanks to an error by Philadelphia's less than surehanded left fielder Greg Luzinski.
Houston took what seemed like a solid 5-2 lead in the seventh on an RBI single by Denny Walling, a wild pitch from Phillies reliever Larry Christenson, and a run-scoring triple by Art Howe. A three run deficit in the eighth inning against Nolan Ryan seemed insurmountable. But the Phillies would not die. They loaded the bases with nobody out on three straight singles, including two infield hits, and then got two runs on a walk to Pete Rose and a groundout by Keith Moreland. An RBI single by Del Unser tied the game 5-5, and then Manny Trillo put the Phillies ahead with a two-run triple.
The Astros promptly came back to tie the game in the bottom of the eighth, with Rafael Landestoy and José Cruz each singling in a run. Neither team scored in the ninth, but the Phillies got doubles from Unser and Garry Maddox in the tenth to take an 8-7 lead. Philadelphia's Dick Ruthven retired the Astros in order in the bottom of the tenth, and the Phillies had won their first pennant since 1950. They went on to defeat the Kansas City Royals four games to two in the World Series.