In his second season, Dickerson continued his onslaught of the NFL record book. As a rookie, Dickerson established rookie records for most rushing attempts (390), most rushing yards gained (1,808) and most touchdowns rushing (18), including another two receiving touchdowns. His efforts earned him All-Pro, Pro Bowl, Player of the Year and Rookie of the Year honors.
Eleven times during the 1984 season, he gained more than 100 yards rushing, breaking the record of 100-yard games in a season held by O.J. Simpson. His 2,105 total yards rushing in the 1984 NFL season beat Simpson's 1973 NFL season record of 2,003 yards rushing in a single season. To date, no one has rushed for more yards in a single NFL season. However, Simpson's career high rushing total came in a 14-game season, whereas Dickerson's mark was set during a 16-game season. Dickerson broke OJ's record with a 215-yard performance in a 27–16 Rams win over the Houston Oilers, Week 15 of the season.
In this Monday Night opener, Rams got off to 13–0 first quarter lead with Eric Dickerson running for a TD, but the Cowboys stormed back behind 343 passing yards by new QB Gary Hogeboom and a defense that held Vince Ferragamo to 11 pass completions in 33 attempts and just 84 yards, and intercepted 5 passes.
Steelers defense held Dickerson to 49 yards and got 2 passing TD's from David Woodley. Ferragamo threw 3 more INT's, giving him nine in three games. He was benched in favor of Jeff Kemp, who would be the starter for the rest of the season.
Dickerson ran for a TD and Kemp passed for another. Bengals scored late on a TD pass from Ken Anderson to Cris Collinsworth and tried an onside kick, but Mike Guman scooped it up and ran for the final TD.
Rams' defense tied an NFL-record by scoring three safeties. They also held the Giants to 8 yards rushing. Henry Ellard returned a punt 83 yards for a TD, and Kemp continued to play mistake-free football, passing for another TD.
Kemp only completed 5 of 14 passes with one TD to Ron Brown and Dickerson rushed for 208 yards; Dickerson accounted for almost all of the Rams' 261 yards of offense. Lansford kicked a FG late to win the game as the Rams defense sacked Neil Lomax six times, three by veteran Jack Youngblood
The 49ers got two early TD passes from Montana and held off a late Ram charge for the win, culminating in a sack for a safety by Gary "Big Hands" Johnson. With this win, the 49ers became the first team in NFL history to win 15 games in an NFL regular season.