August 1 – As was the case last season, Deion Sanders leaves the Atlanta Braves to report for Atlanta Falcons training camp. However, he was able to rework his NFL contract and reported back to the Braves for the postseason.
September 7 – After receiving an 18-9 no-confidence vote from the owners, Commissioner Fay Vincent is forced to resign. Vincent is soon replaced by Milwaukee Brewers president Bud Selig on what is meant to be an interim basis.
October 24 – The Toronto Blue Jays clinch their first World Series championship with a 4–3 win over the Atlanta Braves in Game 6. Dave Winfield's 2–out, 2–run double in the top of the 11th gives Toronto a 4–2 lead. The Braves score one run in the bottom half of the inning and have the tying run on the 3rd when the final out is made. Jimmy Key wins the game in relief, and Candy Maldonado homers for Toronto. Blue Jays catcher Pat Borders, with a .450 batting average, is named the Series MVP. The Toronto Blue Jays finish the season without being swept in any series. It is the first team from outside the United States to win the World Series.
November 12 – Arbitrator George Nicolau overturns the lifetime ban of New York Yankees pitcher Steve Howe for substance abuse, considering it too severe. After that, Howe is re-signed by the team.
November 16 – The Colorado Rockies sign free agent first baseman Andrés Galarraga, who rejoins Don Baylor, his hitting coach with the St. Louis Cardinals. Galarraga is coming off his second injury-plagued year, having missed 44 days of the season after being hit on the wrist by a Wally Whitehurst pitch in the third game of the season.
November 22 – Milwaukee Brewers shortstop Pat Listach is named American League Rookie of the Year. Listach, who was recalled on April 7 to replace the injured Bill Spiers, hit a .290 average and also became the first Brewers player to steal 50 bases in a season.
November 29 – Cincinnati Reds owner Marge Schott is quoted in the New York Times as saying that Adolf Hitler was initially good for Germany, that her references to "niggers" were in jest, and she couldn't understand why the word "Jap" was offensive. MLB appoints a four-man committee to investigate the controversial Schott.
January 1 – Buck Stanton, 85, outfielder for the 1931 St. Louis Browns.
January 3 – George Meyer, 82, second baseman for the 1938 Chicago White Sox.
January 11 – Orville Jorgens, pitcher for the Philadelphia Phillies from 1935 to 1937.
January 15 – Charlie Gassaway, 73, pitcher who spent three seasons with the Chicago Cubs (1944), Philadelphia Athletics (1945) and Cleveland Indians (1946).
January 17 – Red Durrett, 70, outfielder for the 1944 Brooklyn Dodgers.
January 18 – Philomena Gianfrancisco, 68, outfielder who played from 1945 through 1948 in the All-American Girls Professional Baseball League.
January 21 – Chuck Rowland, 92, backup catcher for the 1923 Philadelphia Athletics.
January 30 – Eddie Taylor, 90, third baseman/shortstop for the 1926 Boston Braves.
January 30 – Coaker Triplett, 80, left fielder for the Cubs, Cardinals and Phillies from 1938 to 1945, who later posted four .300 seasons with the Buffalo Bisons of the International League, including the 1950 batting title.
April 2 – Dib Williams, 82, middle infielder for the Philadelphia Athletics and Boston Red Sox from 1930 through 1935, and a member of the 1931 Athletics American League champion team.
April 13 – Steve Shemo, 77, backup infielder for the Boston Braves from 1944 to 1945.
April 15 – Ralph Weigel, 70, catcher/outfielder who played in part of three seasons with the Cleveland Indians (1946), Chicago White Sox (1948) and Washington Senators (1949).
April 20 – Pat Creeden, 85, second baseman for the 1931 Boston Red Sox.
April 20 – Orval Grove, 72, All-Star pitcher who posted a 63-73 record and a 3.78 ERA for the Chicago White Sox from 1940 to 1949, while setting a team-record by winning his first nine decisions in 1943.
April 23 – Deron Johnson, 53, first and third baseman who spent 16 seasons in the majors, while hitting .287 with 32 home runs and a National League-best 130 RBIs for the 1965 Cincinnati Reds, and also a member of the World Series champion Oakland Athletics in 1973.
April 24 – Elio Chacón, 55, Venezuelan middle infielder who led the New York Mets in stolen bases in their 1962 inaugural season.
April 25 – Bob Hazle, 61, right fielder for the Cincinnati Reds, Milwaukee Braves and Detroit Tigers in part of three seasons spanning 1955–1958, and a member of the 1957 World Series champion Braves.
April 27 – Harlond Clift, 79, All-Star third baseman for the St. Louis Browns (1934–1942) and Washington Senators (1942–1945); the first man at his position to hit at least 30 home runs (34, in 1938), who also scored 100 runs seven times, set a record with 405 assists in 1937, and compiled a career-mark of 309 double plays which ranks him 23rd in the MLB all-time list.
May 1 – Celerino Sánchez, 48, Mexican third baseman for the Yankees from 1972 to 1973, who won the 1966 Triple Crown in the Mexican League, also a member of the Mexican and Caribbean Baseball Halls of Fame.
May 1 – Justin Stein, 80, backup infielder who played for the Philadelphia Phillies and the Cincinnati Reds during the 1938 season.
May 8 – Joyce Ricketts, 59, two-time All-Star outfielder in the All-American Girls Professional Baseball League.
May 10 – Tom Seats, 81, pitcher for the Detroit Tigers (1940) and the Brooklyn Dodgers (1945).
May 25 – Otto Denning, 79, catcher who played from 1942 through 1943 for the Cleveland Indians, later a minor league manager.
May 28 – Charley Schanz, 72, hard-throwing pitcher whose career extended for 17 seasons (1938–1954), including stints with the Philadelphia Phillies (1944–1947) and Boston Red Sox (1950).
May 31 – Karl Schnell, 92, relief pitcher for the Cincinnati Reds in the 1922 and 1923 seasons.
June 4 – Carl Stotz, 82, founder of Little League Baseball in 1939 who left the organization in 1955 in a litigious leadership dispute, shortly after serving as a pallbearer at Cy Young's funeral.
June 12 – Randy Moore, 85, right fielder for the Chicago White Sox (1927–28), Boston Braves (1930–35), Brooklyn Dodgers (1936–37) and St. Louis Cardinals (1937).
June 13 – Len Rice, 73, backup catcher for the Cincinnati Reds (1944) and the Chicago Cubs (1945).
June 15 – Eddie Lopat, 73, All-Star pitcher who combined with Allie Reynolds and Vic Raschi to form the heart of the New York Yankees rotation through five World Series championships from 1949 through 1953, while also leading the American League in both earned run average (2.42) and won-lost percentage (.800) in 1953.
June 16 – Rita Meyer, 65, shortstop and pitcher who played in the All-American Girls Professional Baseball League.
June 24 – Vern Curtis, 72, pitcher in parts of three seasons for the Washington Senators between 1943 and 1946.
June 27 – Sandy Amorós, 62, Cuban left fielder for the Brooklyn Dodgers, best remembered for a spectacular catch in Game 7 of the 1955 World Series.
June 27 – Frank Jelincich, 74, outfielder who played briefly for the Chicago Cubs in the 1941 season.
June 27 – Woody Main, 70, pitcher for the Pittsburgh Pirates in parts of four seasons spanning 1948–1953.
July 3 – George Staller, 76, backup outfielder for the 1943 Philadelphia Athletics, who later developed a distinguished career as a scout, also serving as first base coach on Earl Weaver's Baltimore Orioles staff from 1968 to 1975, while working on the Orioles' three consecutive American League championship teams (1969–1971) and the 1970 World Series champion.
July 10 – Walt Masters, 85, Canadian pitcher who played for the Washington Senators (1931), Philadelphia Phillies (1937) and Philadelphia Athletics (1939), and also an American football halfback and quarterback in the National Football League during three seasons between 1936 and 1944.
July 27 – Salty Parker, 80, backup infielder for the 1936 Detroit Tigers, who later posted a 20-year minor league managing record of 920–858 (.517), and also coached for the San Francisco Giants, Cleveland Indians, Los Angeles/California Angels, New York Mets and Houston Astros between 1958 and 1972, while serving brief stints as manager of the Mets (1967) and the Astros (1972).
August 5 – Jim Marquis, 91, pitcher who played briefly for the New York Yankees during the 1925 season.
August 5 – Lefty Wilkie, 77, Canadian pitcher who played for the Pittsburgh Pirates from 1941 to 1942 and again in 1946.
August 29 – Andy Gilbert, 78, outfielder for the Boston Red Sox in 1942 and 1946, who later became a successful minor league manager, while posting a record of 2055–1959 (.512) during 29 seasons spanning 1950–1982, which included five League Championships.
September 5 – Ron Davis, 50, outfielder who played from 1962 through 1969 for the Houston Colt .45s/Astros, St. Louis Cardinals and Pittsburgh Pirates, while collecting a .233 average with 10 home runs and 79 RBIs in 295 games.
September 5 – Billy Herman, 83, Hall of Fame second baseman and a 10-time All-Star for the Chicago Cubs, Brooklyn Dodgers, Boston Braves and Pittsburgh Pirates between 1931 and 1947, who batted a .304 lifetime average, scored 100 runs five times, and led the National League in hits, doubles and triples once each and in putouts seven times, while also managing the Pirates in 1947 and the Boston Red Sox from 1964 through 1966.
September 22 – Aurelio López, 44, All-Star Mexican relief pitcher who posted a 62-36 record with a 3.56 ERA and 93 saves in 11 seasons for the Kansas City Royals, St. Louis Cardinals, Detroit Tigers and Houston Astros, which included two seasons of 21 saves for the Tigers from 1979 to 1980.
September 23 – Bernice Gera, 61, who became the first female umpire to officiate a professional baseball game, which took place on June 24, 1972, in the New York–Penn League in Geneva, New York.
September 27 – Hal Smith, 90, middle-relief pitcher who posted a 12-11 record and a 3.77 ERA in 51 games for the Pittsburgh Pirates from 1932 to 1935.
October 9 – Mike Guerra, 79, Cuban catcher who played for the Washington Senators, Philadelphia Athletics and Boston Red Sox during 10 seasons spanning 1937–1951, and also a manager in the minors and the Mexican and Venezuelan winter leagues.
October 15 – Jackie Sullivan, 74, second baseman who played in one game for the Detroit Tigers in 1944.
October 17 – John O'Connell, 88, backup catcher for the Pittsburgh Pirates in 1928 and 1929.
October 19 – Atley Donald, 82, New York Yankees pitcher who had a lifetime record of 65-33 for a winning percentage of .663, and also was a member of the 1941 World Series champion Yankees.
October 20 – Spider Wilhelm, 63, shorstop for the 1953 Philadelphia Athletics.
October 21 – Joe Dwyer, 89, pinch-hitter in 12 games for the 1937 Cincinnati Reds.
October 22 – Red Barber, 84, broadcaster for the Cincinnati Reds, Brooklyn Dodgers and New York Yankees from 1934 to 1966 who, along with pal Mel Allen, earned the Ford Frick Award honors in its first class from the Baseball Hall of Fame and Museum.
October 23 – Lou Rochelli, 73, second baseman in five games for the 1944 Brooklyn Dodgers; one of many ballplayers who only appeared in the major leagues during World War II.
December 1 – Chile Gómez, 91, Mexican infielder for the Philadelphia Phillies between 1935 and 1942.
December 1 – Sam Lowry, 72, pitcher who played for the Philadelphia Athletics during the 1942 and 1943 seasons.
December 10 – Babe Phelps, 84, catcher for the Washington Senators, Chicago Cubs, Brooklyn Dodgers and Pittsburgh Pirates in a span of 11 seasons from 1931 to 1942, whose .367 batting average in 1936 remains the highest for any major league catcher in the modern era (1901–present).
December 12 – Rube Walker, 66, backup catcher for the Chicago Cubs and the Dodgers in Brooklyn and Los Angeles, later a longtime pitching coach for the Washington Senators, New York Mets and Atlanta Braves, who developed and nurtured the five-man rotation, including the pitching staff of the 1969 Amazin' Mets.
December 15 – Dick Mulligan, 74, pitcher who played in parts of three seasons with the Washington Senators (1941), Philadelphia Phillies (1946) and Boston Braves (1946–1947).
December 25 – Ed Donnelly, 60, pitcher for the 1959 Chicago Cubs.
December 26 – Tom Gorman, 67, relief pitcher who played from 1952 to 1959 for the New York Yankees and the Kansas City Athletics.
December 28 – Sal Maglie, 75, All-Star pitcher for all three New York teams during the 1950s, whose hardnosed style personified the rivalry between the Big Apple Franchises, while posting a 119-62 record and a 3.15 ERA in 303 career appearances, including National League's top marks in wins (1951) and ERA (1950).