Note: All teams played 144 games instead of the normal 162 as a consequence of the 1994–95 Major League Baseball strike. Seattle and California each played 145 games due to a one game AL West tiebreaker.
September 6 – Cal Ripken, Jr. of the Baltimore Orioles plays in his 2,131st consecutive major league game to surpass Lou Gehrig's 56-year record. When the game becomes official in the middle of the fifth inning, Ripken takes a victory lap around Camden Yards during the 22-minute standing ovation from the sellout crowd, including President Bill Clinton. In the game, Ripken goes 2-for-4, including a home run, in Baltimore's 4-2 win over California. It is baseball's most memorable moment in the 1990s.
September 25 – In a 7-0 victory over the St. Louis Cardinals at Wrigley Field, Frank Castillo of the Chicago Cubs has a no-hitter broken up with two out in the ninth—by inches. Bernard Gilkey hits a line drive to right field and despite an all-out attempt by Sammy Sosa to make a diving catch, the ball falls in for a hit and eventually rolls to the wall for a triple, the Cardinals' lone hit of the game. The near no-hitter is almost the first by a Cub pitcher and the first one the Cubs are involved in, since Milt Pappas in 1972.
September 28 – Greg A. Harris of the Montreal Expos becomes the first major league pitcher since 1893 to pitch with both hands in one game. Harris faces four batters, two from his usual right side and two from the left, in the ninth inning of a 9–7 loss to the Cincinnati Reds.
November 9 – Los Angeles Dodgers pitcher Hideo Nomo is named National League Rookie of the Year, becoming the first Japanese player ever to win a Major League award. Nomo posts a 13-6 record with 236 strikeouts and a 2.54 ERA in 1911⁄3 innings of work.
March 5 – Roy Hughes, 84, infielder for four teams who scored 112 runs for 1936 Indians.
March 13 – Leon Day, 78, All-Star pitcher for the Newark Eagles of the Negro Leagues, who set several league strikeout marks, including 18 victims in one game, and was elected to the Hall of Fame just six days before his death.
March 29 – Terry Moore, 82, All-Star center fielder for the St. Louis Cardinals, who batted .304 in 1940, and captained the 1942 and 1946 World Series champions.
April 7 – Frank Secory, 82, National League umpire from 1952 to 1970 who worked in four World Series, six All-Star Games and nine no-hitters, previously a Chicago Cubs outfielder, well known for a pivotal hit in the 1945 World Series.
April 9 – Bob Allison, 60, All-Star outfielder for the Washington Senators and Minnesota Twins, who earned the 1959 American League Rookie of the Year award, had three 30-home run seasons, and led the league in triples and runs once each.
May 4 – Connie Wisniewski, 73, four-time All-American Girls Professional Baseball League All-Star pitcher and outfielder, who set several records in the circuit in an nine-year career from 1944 through 1952.
May 7 – Gus Bell, 66, All-Star outfielder, mainly with the Cincinnati Reds, who had four 100-RBI seasons, led the National League in triples in 1951, and was the oldest in a Major League family that includes his son Buddy and his grandson David.
June 9 – Zoilo Versalles, 55, Cuban All-Star shortstop who led the Minnesota Twins to the 1965 American League pennant, as well as the first Latin American player to being named MVP, while leading the league in triples three times and in doubles and runs once each.
June 10 – Lindsey Nelson, 76, broadcaster for the New York Mets from 1962 to 1979, and later for the San Francisco Giants and NBC.
July 4 – Adeline Kerrar, 70, All-American Girls Professional Baseball League catcher and infielder.
July 27 – Rick Ferrell, 89, Hall of Fame catcher for the St. Louis Browns, Boston Red Sox and Washington Senators, whose 1806 career-games caught were an American League record until 1988, and also was the half of a battery with his brother Wes Ferrell from 1934 to 1938.
August 1 – Ruby Knezovich, 77, Canadian catcher who played from 1943 to 1944 in the All-American Girls Professional Baseball League.
August 3 – Harry Craft, 80, manager of the Houston Colt .45s in their 1962 debut, who also managed the Kansas City Athletics and Chicago Cubs, and previously was a Cincinnati Reds center fielder.
August 4 – Dick Bartell, 87, All-Star shortstop for five teams, known for his combative personality, who batted .300 five times and scored 100 runs three times, while batting .381 for the New York Giants in the 1936 World Series.
August 13 – Mickey Mantle, 63, Hall of Fame center fielder and powerful switch-hitter for the New York Yankees, and successor to Babe Ruth and Joe DiMaggio as symbol of the Yankees' long reign, who earned the American League MVP Award from 1956–1957 and in 1962; set a record with 18 home runs in World Series play; was a 10-time .300 hitter and led the AL in runs six times to set an all-time record, while winning the 1956 Triple Crown, 16-time All-Star selections, four home run titles –hitting 50 twice–, and retiring with the third most career HRs (536) and walks (1733) in MLB history, including career marks for runs (1677), RBI (1509) and slugging percentage (.557).
August 20 – Von McDaniel, 56, pitcher who joined his brother Lindy on the 1957–1958 St. Louis Cardinals, winning seven games.
September 7 – Al Papai, 78, knuckleballer specialist for four major league teams from 1948–55, and one of 29 players to pitch for both St. Louis clubs.
September 21 – Tony Cuccinello, 87, All-Star second baseman for five teams during 15 seasons spanning 1930–1945, who lost the American League batting title by one point in his final season, and later became a coach.
September 21 – Andrew Rozdilsky, 77, who performed as Andy the Clown at White Sox games from 1960 to 1990.
October 21 – Vada Pinson, 57, All-Star center fielder for the Reds and four other teams who batted .300 four times and led NL in hits, doubles and triples twice each; second player to hit 250 home runs and steal 300 bases.
October 29 – Al Niemiec, 84, second baseman who played from 1934 to 1936 for the Boston Red Sox and Philadelphia Athletics.
November 19 – Ed Wright, 76, pitcher for the Boston Braves and Philadelphia Athletics between 1945 and 1952, who also threw a no-hitter in the American Association (1945) and the first shutout in Caribbean Series history in 1949.
November 24 – Irene Hickson, 80, All-Star catcher who played in the All-American Girls Professional Baseball League in a span of nine seasons from 1943–1950.