Note: All teams played 144 games instead of the normal 162 as a consequence of the 1994–95 Major League Baseball strike. Seattle and California each played 145 games due to a one game AL West tiebreaker.
September 6 – Cal Ripken, Jr. of the Baltimore Orioles plays in his 2,131st consecutive major league game to surpass Lou Gehrig's 56-year record. When the game becomes official in the middle of the fifth inning, Ripken takes a victory lap around Camden Yards during the 22-minute standing ovation from the sellout crowd, including President Bill Clinton. In the game, Ripken goes 2-for-4, including a home run, in Baltimore's 4-2 win over California. It is baseball's most memorable moment in the 1990s.
September 25 – In a 7-0 victory over the St. Louis Cardinals at Wrigley Field, Frank Castillo of the Chicago Cubs has a no-hitter broken up with two out in the ninth—by inches. Bernard Gilkey hits a line drive to right field and despite an all-out attempt by Sammy Sosa to make a diving catch, the ball falls in for a hit and eventually rolls to the wall for a triple, the Cardinals' lone hit of the game. The near no-hitter is almost the first by a Cub pitcher and the first one the Cubs are involved in, since Milt Pappas in 1972.
September 28 – Greg A. Harris of the Montreal Expos becomes the first major league pitcher since 1893 to pitch with both hands in one game. Harris faces four batters, two from his usual right side and two from the left, in the ninth inning of a 9–7 loss to the Cincinnati Reds.
November 9 – Los Angeles Dodgers pitcher Hideo Nomo is named National League Rookie of the Year, becoming the first Japanese player ever to win a Major League award. Nomo posts a 13-6 record with 236 strikeouts and a 2.54 ERA in 1911⁄3 innings of work.
January 2 – Don Elston, 65, All-Star relief pitcher for the Cubs who led NL in appearances in 1958 and 1959
January 3 – Jim Tyack, 83, outfielder for the 1943 Philadelphia Athletics
January 12 – John "Hi" Simmons, 89, coach at Missouri from 1937 to 1973 who won the 1954 College World Series
January 18 – Ron Luciano, 57, American League umpire from 1968 to 1980 known for his flamboyance and several books
February 7 – Cecil Upshaw, 52, relief pitcher, mainly for the Atlanta Braves, who saved 27 games in 1969 but missed the next season after nearly severing a finger
March 5 – Roy Hughes, 84, infielder for four teams who scored 112 runs for 1936 Indians
March 13 – Leon Day, 78, All-Star pitcher for the Newark Eagles of the Negro Leagues who was elected to the Hall of Fame just six days earlier; set several league strikeout marks, including 18 victims in one game
March 29 – Terry Moore, 82, All-Star center fielder for the Cardinals who batted .304 in 1940, captained 1942 and 1946 champions
April 7 – Frank Secory, 82, National League umpire from 1952 to 1970 who worked in four World Series, six All-Star Games and nine no-hitters; as Cubs outfielder, had a pivotal hit in the 1945 World Series
April 9 – Bob Allison, 60, All-Star outfielder for the Senators/Twins who was the 1959 Rookie of the Year, had three 30-HR seasons and led the AL in triples and runs once each
May 4 – Connie Wisniewski, 73, four-time All-American Girls Professional Baseball League All-Star pitcher and outfielder, who set several records in the circuit in an eight-year career
May 7 – Gus Bell, 66, All-Star outfielder, mainly with the Reds, who had four 100-RBI seasons and led the NL in triples in 1951; oldest in a major league family that includes son Buddy and grandson David
May 18 – Jack Kramer, 77, three-time All-Star pitcher who led the St. Louis Browns to their only World Series appearance in 1944
May 30 – Glenn Burke, 42, center fielder for the Dodgers and Athletics who was the first former major leaguer to publicly acknowledge his homosexuality
June 9 – Zoilo Versalles, 55, Cuban All-Star shortstop who led Twins to the 1965 AL pennant; first Latin American player to be named MVP, led AL in triples three times and in doubles and runs once each
June 10 – Lindsey Nelson, 76, broadcaster for the Mets from 1962 to 1979, and also for the San Francisco Giants and NBC
July 4 – Adeline Kerrar, 70, All-American Girls Professional Baseball League catcher and infielder
July 27 – Rick Ferrell, 89, Hall of Fame catcher for the Browns, Red Sox and Senators whose 1806 games caught were an AL record until 1988; from 1934–38, half of a battery with brother Wes
August 3 – Harry Craft, 80, manager of the Houston Colt .45s in their 1962 debut; former Reds center fielder also managed the Kansas City Athletics and Chicago Cubs
August 4 – Dick Bartell, 87, All-Star shortstop for five teams, known for his combative personality, who batted .300 five times and scored 100 runs three times; batted .381 for Giants in 1936 World Series
August 13 – Mickey Mantle, 63, Hall of Fame center fielder for the Yankees who was the AL's MVP in 1956, 1957 and 1962 and won the 1956 Triple Crown; 16-time All-Star won four home run titles, hitting 50 twice, and retired with third most HRs (536) and walks (1733) in history; 10-time .300 hitter led AL in runs six times; most powerful switch-hitter in baseball history, with career marks for runs (1677), RBI (1509) and slugging percentage (.557), and successor to Babe Ruth and Joe DiMaggio as symbol of the Yankees' long reign; hit record 18 home runs in World Series play
August 20 – Von McDaniel, 56, pitcher who joined his brother Lindy on the 1957–58 St. Louis Cardinals, winning seven games
September 7 – Al Papai, 78, knuckleballer specialist for four major league teams from 1948–55, and one of 29 players to pitch for both St. Louis clubs
September 21 – Tony Cuccinello, 87, All-Star second baseman for five teams who lost 1945 batting title by one point in his final season; later a coach
September 21 – Andrew Rozdilsky, 77, who performed as Andy the Clown at White Sox games from 1960 to 1990
October 21 – Vada Pinson, 57, All-Star center fielder for the Reds and four other teams who batted .300 four times and led NL in hits, doubles and triples twice each; second player to hit 250 HRs and steal 300 bases
October 29 – Al Niemiec, 84, second baseman who played from 1934 to 1936 for the Boston Red Sox and Philadelphia Athletics
November 19 – Ed Wright, 76, pitcher for the Boston Braves and Philadelphia Athletics between 1945 and 1952, who also threw a no-hitter in the American Association (1945) and the first shutout in Caribbean Series history (1949)
November 24 – Irene Hickson, 80, All-Star catcher who played during nine seasons in the All-American Girls Professional Baseball League (1943–1950)
November 30 – Jim Davis, 69, pitcher for the Chicago Cubs, St. Louis Cardinals and New York Giants from 1954 to 1957, who in 1956 became the first pitcher in 40 years to record four strikeouts in a single inning
November 30 – William Suero, 29, Dominican infielder for the Milwaukee Brewers from 1992–93
December 2 – Art Herring, 89, pitcher for the Detroit Tigers, Brooklyn Dodgers, Chicago White Sox and Pittsburgh Pirates between 1929 and 1947
December 5 – Bill Bruton, 70, center fielder for the Braves and Tigers who led the NL in steals three times, triples twice and runs once
December 20 – Betty Wanless, 67, All-American Girls Professional Baseball League infielder
December 27 – Al Barlick, 80, Hall of Fame umpire for 28 National League seasons between 1940 and 1971; worked seven World Series and a record seven All-Star Games
December 27 – Oscar Judd, 87, Canadian pitcher who was an American League All-Star in 1943