|Chemical and physical data|
|Molar mass||379.50 g·mol−1|
|3D model (JSmol)|
1P-LSD or 1-propionyl-lysergic acid diethylamide is a psychedelic drug of the lysergamide class that is a derivative and functional analog of LSD and a homolog of ALD-52. It has been sold online as a designer drug since 2015.
While 1P-LSD shows only 38% the potency of LSD in mice, LSD is detected via LC-MS when 1P-LSD is incubated in human serum. This implies that 1P-LSD acts as a prodrug for LSD. This partially explains the effects of 1P-LSD, because the compound itself is unable to bind to the 5-HT2A receptors responsible for the effects of psychedelic drugs.
|“||I am sure that the 1-propionyl would also hydrolyze off of an indole, but I don't know whether in vivo conditions would work. In a chemistry lab, you can get off an N-benzoyl, so an N-propionyl will probably come off too. But in the body? I don't know the answer to that. The compound would not be active as the N-propionyl however. The way that LSD docks into the 5-HT2A receptor, the indole NH hydrogen bonds to serine 5.46. With the propionyl, it won't fit into the receptor.||”|
The effects profile of 1P-LSD is not well defined. It is generally thought to be comparable to that of LSD.
1P-LSD is illegal in Belgium since 26 September 2017.
1P-LSD is illegal in Denmark.
1p-LSD is illegal in Finland.
1P-LSD is illegal in Japan since 18 April 2016.
1P-LSD is illegal in Latvia. Although it isn't specifically scheduled, it is controlled as an LSD structural analog due to an amendment made on June 1, 2015.
1p-LSD is illegal in Lithuania.
1P-LSD is illegal in Norway.
1P-LSD is legal in Poland.
Public Health Agency of Sweden added 1p-LSD as health hazard under the act Act on the Prohibition of Certain Goods Dangerous to Health (SFS 1999:42) in Sweden as of January 26, 2016, published in SFS 2015:997 listed as N,N-dietyl-6-metyl-1-propionyl-9,10-didehydroergolin-8-karboxamid (1p-LSD).
1P-LSD is illegal in Switzerland.
While 1P-LSD is not controlled at the federal level in the United States, it's possible that 1P-LSD could be considered as an analog of LSD, in which case trade or possession with intent for human consumption could be prosecuted under the Federal Analogue Act.
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