|Chemical and physical data|
|Molar mass||379.50 g·mol−1|
|3D model (JSmol)|
1P-LSD or 1-propionyl-lysergic acid diethylamide is a psychedelic drug of the lysergamide class that is a derivative and functional analogue of LSD and a homologue of ALD-52. It has been sold online as a designer drug since 2015.
In mice, 1P-LSD produces LSD-like effects with 38% the potency of LSD and it is therefore classed as a serotonergic hallucinogen. However, 1P-LSD itself is unable to bind to the serotenergic 5-HT2A receptors. But since LSD is detected when 1P-LSD is incubated in human serum, 1P-LSD may act, at least in part, as a prodrug for LSD.
|“||I am sure that the 1-propionyl would also hydrolyze off of an indole, but I don't know whether in vivo conditions would work. In a chemistry lab, you can get off an N-benzoyl, so an N-propionyl will probably come off too. But in the body? I don't know the answer to that. The compound would not be active as the N-propionyl however. The way that LSD docks into the 5-HT2A receptor, the indole NH hydrogen bonds to serine 5.46. With the propionyl, it won't fit into the receptor.||”|
The effects profile of 1P-LSD is not well defined in the scientific literature. It is generally thought to be comparable to that of LSD. Many anecdotal reports indicate that 1P-LSD has a slightly shorter duration than LSD in humans, with the majority of users stating that they cannot distinguish the qualitative effects of 1P-LSD from LSD.
1P-LSD is illegal in Belgium since 26 September 2017.
1P-LSD is illegal in Denmark.
1P-LSD is illegal in Finland.
1P-LSD is illegal in Japan since 18 April 2016.
1P-LSD is illegal in Latvia. Although it isn't specifically scheduled, it is controlled as an LSD structural analog due to an amendment made on June 1, 2015.
1P-LSD is illegal in Norway.
Public Health Agency of Sweden added 1P-LSD as health hazard under the act Act on the Prohibition of Certain Goods Dangerous to Health (SFS 1999:42) in Sweden as of January 26, 2016, published in SFS 2015:997 listed as N,N-dietyl-6-metyl-1-propionyl-9,10-didehydroergolin-8-karboxamid (1P-LSD).
1P-LSD is illegal in Switzerland.
While 1P-LSD is not controlled at the federal level in the United States, it's possible that 1P-LSD could be considered as an analogue of LSD, in which case trade or possession with intent for human consumption could be prosecuted under the Federal Analogue Act.
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