This was an area of Uptown New Orleans urbanized in the early decades of the 19th century. A series of streets perpendicular to the River are named after the Muses of Classical Greek Mythology.
Despite the "First" designation, this was neither the oldest section of the city nor its seat of government. The current "1st Ward" was a result of a redrawing of divisions within the city in 1852, prior to which the city had been governed for a generation as 3 separate municipalities, each with its own wards. The First Ward of the newly unified city was designated as identical to the boundaries of the First Ward of the old 2nd Municipality as designated in 1847.