2β-Propanoyl-3β-(4-tolyl)-tropane

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2β-Propanoyl-3β-(4-tolyl)-tropane
WF-11.svg
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
Formula C18H25NO
Molar mass 271.397 g/mol
3D model (Jmol)

2β-Propanoyl-3β-(4-tolyl)-tropane also known as WF-11 or 2-PTT is a cocaine analogue 20 times more potent than cocaine at binding to the dopamine transporter with increased selectivity for the norepinephrine transporters. It also shows marked increase in metabolic stability. In contrast to the findings of cocaine effects, WF-11 has been shown to produce a uniform downregulation of tyrosine hydroxylase protein and activity gene expression with a regimen of use.[1]

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References[edit]

  1. ^ Freeman, Willard M; Yohrling IV, George J; Daunais, James B; Gioia, Lynda; Hart, Stephanie L; Porrino, Linda J; Davies, Huw M. L; Vrana, Kent E (22 December 2000). "A cocaine analog, 2β-propanoyl-3β-(4-tolyl)-tropane (PTT), reduces tyrosine hydroxylase in the mesolimbic dopamine pathway". Drug and Alcohol Dependence. 61 (1): 15–21. doi:10.1016/S0376-8716(00)00119-8. PMID 11064180.