2β-Propanoyl-3β-(4-tolyl)-tropane also known as WF-11 or 2-PTT is a cocaineanalogue 20 times more potent than cocaine at binding to the dopamine transporter with increased selectivity for the norepinephrine transporters. It also shows marked increase in metabolic stability. In contrast to the findings of cocaine effects, WF-11 has been shown to produce a uniform downregulation of tyrosine hydroxylase protein and activity gene expression with a regimen of use.
^Freeman, Willard M; Yohrling IV, George J; Daunais, James B; Gioia, Lynda; Hart, Stephanie L; Porrino, Linda J; Davies, Huw M. L; Vrana, Kent E (22 December 2000). "A cocaine analog, 2β-propanoyl-3β-(4-tolyl)-tropane (PTT), reduces tyrosine hydroxylase in the mesolimbic dopamine pathway". Drug and Alcohol Dependence. 61 (1): 15–21. doi:10.1016/S0376-8716(00)00119-8. PMID11064180.