2,6-dioxo-6-phenylhexa-3-enoate hydrolase

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2,6-dioxo-6-phenylhexa-3-enoate hydrolase
EC number
CAS number 102925-38-2
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a 2,6-dioxo-6-phenylhexa-3-enoate hydrolase (EC is an enzyme that catalyzes the chemical reaction

2,6-dioxo-6-phenylhexa-3-enoate + H2O benzoate + 2-oxopent-4-enoate

Thus, the two substrates of this enzyme are 2,6-dioxo-6-phenylhexa-3-enoate and H2O, whereas its two products are benzoate and 2-oxopent-4-enoate.

This enzyme belongs to the family of hydrolases, specifically those acting on carbon-carbon bonds in ketonic substances. The systematic name of this enzyme class is 2,6-dioxo-6-phenylhexa-3-enoate benzoylhydrolase. This enzyme is also called HOHPDA hydrolase. This enzyme participates in biphenyl degradation and fluorene degradation.

Structural studies[edit]

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1C4X, 1J1I, and 2OG1.


  • Omori T, Sugimura K, Ishigooka H, Minoda Y (1986). "Purification and some properties of a 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolyzing enzyme from Pseudomonas cruciviae S93 B1 involved in the degradation of biphenyl". Agric. Biol. Chem. 50: 931–937. doi:10.1271/bbb1961.50.931.