2,8-Dihydroxyhexahydrochrysene

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2,8-Dihydroxyhexahydrochrysene
2,8-Dihydroxyhexahydrochrysene.svg
Clinical data
ATC code
  • None
Chemical and physical data
Formula C18H18O2
Molar mass 266.34 g·mol−1

2,8-Dihydroxyhexahydrochrysene (2,8-DHHHC) is a synthetic, nonsteroidal weak estrogen with approximately 1/2,000th the estrogenic potency of the structurally-related estrogen diethylstilbestrol.[1][2][3] It is said to be intermediate in structure between estradiol and hexestrol, but conversely to both of them, is drastically less potent in comparison.[3]

See also[edit]

References[edit]

  1. ^ Philipp Y. Maximov; Russell E. McDaniel; V. Craig Jordan (23 July 2013). Tamoxifen: Pioneering Medicine in Breast Cancer. Springer Science & Business Media. pp. 4–. ISBN 978-3-0348-0664-0. 
  2. ^ Virgil Craig Jordan (1986). Estrogen/antiestrogen Action and Breast Cancer Therapy. Univ of Wisconsin Press. pp. 22–. ISBN 978-0-299-10480-1. 
  3. ^ a b Wilds, A. L.; Sutton, Reid E. (1951). "Cyclic Analogs of Hexestrol in the Chrysene Series". The Journal of Organic Chemistry. 16 (9): 1371–1379. doi:10.1021/jo50003a006. ISSN 0022-3263.