2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase

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2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase
Identifiers
EC number 3.5.1.66
CAS number 95829-26-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase (EC 3.5.1.66) is an enzyme that catalyzes the chemical reaction

2-(hydroxymethyl)-3-(acetamidomethylene)succinate + 2 H2O acetate + 2-(hydroxymethyl)-4-oxobutanoate + NH3 + CO2

Thus, the two substrates of this enzyme are 2-(hydroxymethyl)-3-(acetamidomethylene)succinate and H2O, whereas its 4 products are acetate, 2-(hydroxymethyl)-4-oxobutanoate, NH3, and CO2.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is 2-(hydroxymethyl)-3-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating). Other names in common use include compound B hydrolase, alpha-hydroxymethyl-alpha'-(N-acetylaminomethylene)succinic acid, and hydrolase. This enzyme participates in vitamin B6 metabolism.

References[edit]

  • Huynh MS, Snell EE (1985). "Enzymes of vitamin B6 degradation. Purification and properties of two N-acetylamidohydrolases". J. Biol. Chem. 260 (4): 2379&ndash, 83. PMID 3972793.