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Legal status
Legal status
  • CA: Schedule I
  • UK: Class B
  • Illegal in Italy, Japan, Latvia, Singapore, Sweden and Switzerland
CAS Number
PubChem CID
Chemical and physical data
Molar mass221.275 g·mol−1
3D model (JSmol)

2-Fluorodeschloroketamine (also known as 2'-Fl-2-Oxo-PCM, Fluoroketamine and 2-FDCK) is a dissociative anesthetic[1] that has been sold online as a designer drug.[2][3][4] It is an analogue of ketamine where the chlorine group has been replaced by fluorine.

Legal status[edit]

2-Fluorodeschloroketamine is illegal in Italy,[5] Japan,[6] Latvia,[7] Singapore,[8] Sweden,[9] Switzerland,[10] as well as being covered by blanket bans in Canada and the UK.

See also[edit]


  1. ^ Moghimi, Abolghasem; Rahmani, Siyavash; Zare, Reza; Sadeghzadeh, Morteza (18 July 2014). "Synthesis of 2-(2-Fluorophenyl)-2-methylamino-Cyclohexanone as a New Ketamine Derivative". Synthetic Communications. 44 (14): 2021–2028. doi:10.1080/00397911.2014.885053. ISSN 0039-7911.
  2. ^ Davidsen, Anders Bork; Mardal, Marie; Holm, Niels Bjerre; Andreasen, Anna Katrine; Johansen, Sys Stybe; Noble, Carolina; Dalsgaard, Petur; Linnet, Kristian (20 February 2020). "Ketamine analogues: Comparative toxicokinetic in vitro–in vivo extrapolation and quantification of 2-fluorodeschloroketamine in forensic blood and hair samples". Journal of Pharmaceutical and Biomedical Analysis. 180: 113049. doi:10.1016/j.jpba.2019.113049. ISSN 0731-7085. PMID 31881397.
  3. ^ Wang, Pan-Fen; Neiner, Alicia; Lane, Thomas R.; Zorn, Kimberley M.; Ekins, Sean; Kharasch, Evan D. (4 February 2019). "Halogen Substitution Influences Ketamine Metabolism by Cytochrome P450 2B6: In Vitro and Computational Approaches". Molecular Pharmaceutics. 16 (2): 898–906. doi:10.1021/acs.molpharmaceut.8b01214. ISSN 1543-8384. PMID 30589555.
  4. ^ Tang, Magdalene H. Y.; Li, Terence C.; Lai, C. K.; Chong, Y. K.; Ching, C. K.; Mak, Tony W. L. (July 2020). "Emergence of new psychoactive substance 2-fluorodeschloroketamine: Toxicology and urinary analysis in a cluster of patients exposed to ketamine and multiple analogues". Forensic Science International. 312: 110327. doi:10.1016/j.forsciint.2020.110327. ISSN 0379-0738. PMID 32460225.
  5. ^ "Aggiornamento delle tabelle contenenti l'indicazione delle sostanze stupefacenti e psicotrope, di cui al decreto del Presidente della Repubblica 9 ottobre 1990, n. 309 e successive modificazioni ed integrazioni. Inserimento nella tabella I e nella tabella IV di nuove sostanze psicoattive". Article 1, Decree of March 13, 2020 (in Italian).
  6. ^ "指定薬物一覧" (PDF) (in Japanese). Ministry of Health, Labour and Welfare.
  7. ^ "Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem" (in Latvian). Latvijas Republikas tiesību akti.
  8. ^ "Misuse of Drugs Act - Singapore Statutes Online". sso.agc.gov.sg.
  9. ^ Riksdagsförvaltningen. "Förordning (1999:58) om förbud mot vissa hälsofarliga varor Svensk författningssamling 1999:1999:58 t.o.m. SFS 2019:631 - Riksdagen". www.riksdagen.se (in Swedish).
  10. ^ "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien" (in German). Der Bundesrat.