2-coumarate reductase

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2-coumarate reductase
Identifiers
EC number 1.3.1.11
CAS number 37251-10-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a 2-coumarate reductase (EC 1.3.1.11) is an enzyme that catalyzes the chemical reaction

3-(2-hydroxyphenyl)propanoate + NAD+ 2-coumarate + NADH + H+

Thus, the two substrates of this enzyme are 3-(2-hydroxyphenyl)propanoate and NAD+, whereas its 3 products are 2-coumarate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase. This enzyme is also called melilotate dehydrogenase. This enzyme participates in phenylalanine metabolism.

References[edit]

  • Levy CC; Weinstein GD (1964). "The metabolism of coumarin by a microorganism. II. The reduction of o-coumaric acid to melilotic acid". Biochemistry. 3 (12): 1944–1947. doi:10.1021/bi00900a027. PMID 14269315.