2-dehydro-3-deoxyglucarate aldolase

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2-dehydro-3-deoxyglucarate aldolase
4tv6.jpg
2-dehydro-3-deoxyglucarate aldolase hexamer, Staphylococcus aureus
Identifiers
EC number4.1.2.20
CAS number37290-56-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a 2-dehydro-3-deoxyglucarate aldolase (EC 4.1.2.20) is an enzyme that catalyzes the chemical reaction

2-dehydro-3-deoxy-D-glucarate pyruvate + tartronate semialdehyde

Hence, this enzyme has one substrate, 2-dehydro-3-deoxy-D-glucarate, and two products, pyruvate and tartronate semialdehyde.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase (pyruvate-forming). Other names in common use include 2-keto-3-deoxyglucarate aldolase, alpha-keto-beta-deoxy-D-glucarate aldolase, and 2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase. This enzyme participates in ascorbate and aldarate metabolism.

Structural studies[edit]

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1DXE, 1DXF, 1W37, 1W3I, 1W3N, and 1W3T.

References[edit]

  • Fish DC, Blumenthal HJ (1966). "2-Keto-3-deoxy-D-glucarate aldolase". Carbohydrate Metabolism. Methods in Enzymology. 9. pp. 529–534. doi:10.1016/0076-6879(66)09105-5. ISBN 978-0-12-181809-8.