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Skeletal formula of hexan-2-one
Ball-and-stick model of hexan-2-one
IUPAC name
Other names
Methyl butyl ketone; Methyl n-butyl ketone; MNBK; Butyl methyl ketone; MBK; n-Butyl methyl ketone; Propylacetone
3D model (Jmol)
ECHA InfoCard 100.008.848
EC Number 209-731-1
RTECS number MP1400000
Molar mass 100.16 g·mol−1
Appearance Colorless to light yellow liquid
Odor sharp, acetone-like[3]
Density 0.8113 g/cm³
Melting point −55.5 °C (−67.9 °F; 217.7 K)
Boiling point 127.6 °C (261.7 °F; 400.8 K)
1.4% (14 g/L)
Vapor pressure 1.3 kPa (20 °C)
-69.1·10−6 cm3/mol
1.403 (20 °C)
Viscosity 0.63 mPa·s (20 °C)
Toxic T
R-phrases (outdated) R10, R48, R23, R62, R67
NFPA 704
Flammability code 3: Liquids and solids that can be ignited under almost all ambient temperature conditions. Flash point between 23 and 38 °C (73 and 100 °F). E.g., gasoline) Health code 2: Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury. E.g., chloroform Reactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g., liquid nitrogen Special hazards (white): no codeNFPA 704 four-colored diamond
Flash point 25 °C (77 °F; 298 K)
423 °C (793 °F; 696 K)
Explosive limits  ?-8%[3]
Lethal dose or concentration (LD, LC):
2590 mg/kg (oral, rat)
2430 mg/kg (oral, mouse)
4860 mg/kg (dermal, rabbit)
2590 mg/kg (oral, guinea pig)[4]
914 mg/kg (rat, oral)[4]
8000 ppm (rat, 4 hr)[4]
20,000 ppm (guinea pig, 70 min)[4]
US health exposure limits (NIOSH):
PEL (Permissible)
TWA 100 ppm (410 mg/m3)[3]
REL (Recommended)
TWA 1 ppm (4 mg/m3)[3]
IDLH (Immediate danger)
1600 ppm[3]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

2-Hexanone (methyl butyl ketone, MBK) is a ketone used as a general solvent and in paints. It dissolves cellulose nitrate, vinyl polymers and copolymers, and natural and synthetic resins. It is recommended as a solvent because it is photochemically inactive;[5] however it has a very low safe threshold limit value. 2-Hexanone is absorbed through the lungs, orally and dermally and its metabolite, 2,5-hexanedione, is neurotoxic.[6] Animal tests have shown that the neurotoxic effect of 2-hexanone may be potentiated by simultaneous administration of 2-butanone (methyl ethyl ketone, MEK).[7]


  1. ^ Merck Index, 11th Edition, 5955.
  2. ^ CRC Handbook of Chemistry and Physics, 75th ed. (1995)
  3. ^ a b c d e "NIOSH Pocket Guide to Chemical Hazards #0325". National Institute for Occupational Safety and Health (NIOSH). 
  4. ^ a b c d "2-Hexanone". Immediately Dangerous to Life and Health. National Institute for Occupational Safety and Health (NIOSH). 
  5. ^ Dieter Stoye (2007), "Solvents", Ullmann's Encyclopedia of Industrial Chemistry (7th ed.), Wiley, p. 56 
  6. ^ Jerrold B. Leikin; Frank P. Paloucek (2008), "2-Hexanone", Poisoning and Toxicology Handbook (4th ed.), Informa, p. 737 
  7. ^ Wilhelm Neier; Günter Strehlke (2007), "2-Butanone", Ullmann's Encyclopedia of Industrial Chemistry (7th ed.), Wiley, p. 6