2-hydroxymethylglutarate dehydrogenase

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2-hydroxymethylglutarate dehydrogenase
Identifiers
EC number 1.1.1.291
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a 2-hydroxymethylglutarate dehydrogenase (EC 1.1.1.291) is an enzyme that catalyzes the chemical reaction

(S)-2-hydroxymethylglutarate + NAD+ 2-formylglutarate + NADH + H+

Thus, the two substrates of this enzyme are (S)-2-hydroxymethylglutarate and NAD+, whereas its 3 products are 2-formylglutarate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-2-hydroxymethylglutarate:NAD+ oxidoreductase. This enzyme is also called HgD.

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