The 2000 Grand Prix de Tennis de Lyon was a men's tennis tournament played on indoor carpet courts at the Palais des Sports de Gerland in Lyon in France and was part of the International Series of the 2000 ATP Tour. It was the 14th edition of the tournament and ran from November 6 through November 13, 2000. Arnaud Clément won the singles title.
Arnaud Clément defeated Patrick Rafter 7–6(7–2), 7–6(7–5)
- It was Clément's 2nd title of the year and the 2nd of his career.
Paul Haarhuis / Sandon Stolle defeated Ivan Ljubičić / Jack Waite 6–1, 6–7, 7–6
- It was Haarhuis' 2nd title of the year and the 51st of his career. It was Stolle's 3rd title of the year and the 16th of his career.