March 12–26 – Pope John Paul II visits Israel, and thus becomes the second pope to visit the Jewish state. During his stay, the Pope visits Yad Vashem (the Israeli national Holocaust memorial) and the Western Wall placing a letter inside it in which he prayed for forgiveness for the actions against Jews in the past.
March 14 – Israel formally deploys its Arrow 2 anti-ballistic missile system.
March 28 – A police investigation recommends that former prime minister Benjamin Netanyahu and his wife be indicted on criminal charges of fraud, bribery, theft of state gifts and obstruction of justice.
October 1–9, 2000: Solidarity demonstrations held by Arab citizens of Israel escalate into clashes with Israeli police and Israeli Jewish citizens. Twelve Israeli Arabs and one Palestinian Arab from the Gaza Strip are shot and killed by the Israeli police. One Israeli Jewish civilian was killed by a rock thought to have been thrown by an Arab citizen.
October 7 – 2000 Hezbollah cross-border raid: Three Israeli soldiers are abducted by Hezbollah while patrolling the Israeli administered side of the Israeli-Lebanese border and Northern Israel is shelled in an attempt to ignite the Israeli-Lebanese border too, but Israelis decide on limited response.
July 11–25 – The Camp David 2000 Summit is held which is aimed at reaching a "final status" agreement. The summit collapses after Yasser Arafat would not accept a proposal drafted by American and Israeli negotiators. Ehud Barak is prepared to offer the entire Gaza Strip, part of East Jerusalem as capital of a Palestinian Arab state, 73% of the West Bank (excluding eastern Jerusalem) raising to 90–94% after 10–25 years, and financial reparations for Palestinian Arab refugees for peace. Arafat turns down the offer without making a counter-offer.
September 28 – Israeli opposition leader Ariel Sharon visits the Temple Mount, protected by a several-hundred-strong Israeli police force. Riots by Palestinian Arabs erupt, leading to a full-fledged armed uprising (called the Al-Aqsa Intifada by sympathizers and the Oslo War by opponents).
November 20 – Kfar Darom bombing: an Israeli school bus was struck by a roadside bomb at the Jewish settlement of Kfar Darom killing 2 adults and injuring several others. Hamas claimed responsibility.
November 22 – Hadera's main street bombing: Two Israeli women are killed and 60 civilians are wounded in a car bomb attack in Hadera. Hamas claimed responsibility.
September 30 – Second Intifada: Muhammad al-Durrah incident – Ten Palestinian Arabs are killed during crossfire between Israeli forces and Palestinian Arab militia at the Netzarim junction, among them the twelve-year old boy Muhammad al-Durrah who is caught in the crossfire and is allegedly killed in the arms of his father. Al-Durrah's death was filmed by a Palestinian Arab freelance cameraman and made worldwide headlines and as a result Al-Durrah became a symbol of the Palestinian Arab uprising in 2000 and of Palestinian martyrdom. Whether the Israeli forces or the Palestinian Arab militia shot the boy is a matter of dispute.
December 17 – Tanzim activist Samih al-Malabi, is assassinated by a mobile phone bomb near the Qalandiyya refugee camp.