2000 in Wales
- Prince of Wales – Charles
- Princess of Wales – vacant
- First Secretary (until 16 October)/First Minister
- Secretary of State for Wales – Paul Murphy
- Archbishop of Wales – Rowan Williams, Bishop of Monmouth
- Archdruid of the National Eisteddfod of Wales – Meirion Evans
- 15 February - Wales child abuse scandal: Sir Ronald Waterhouse publishes the report of his inquiry into abuse in children's homes in north Wales.
- 24 May - National Botanic Garden of Wales opened near Llanarthney in the Towy Valley, Carmarthenshire (official opening by the Prince of Wales: 21 July).
- August - National Eisteddfod of Wales held at Llanelli.
- 15 October - Dedication of the new organ at St David's Cathedral.
- 16 October - Rhodri Morgan's official title as leader of the Welsh Assembly is changed from First Secretary to First Minister. The post of Deputy First Minister for Wales is simultaneously created, and Mike German is appointed.
- 18 November - Catherine Zeta-Jones marries Michael Douglas at the Plaza Hotel, New York City.
- 14 December - Penderyn whisky begins production.
- The Cardiff Bay Development Corporation is wound up, having achieved its main objective of regenerating the former docklands of Cardiff.
- The Royal Glamorgan Hospital opens at Ynysmaerdy, Talbot Green, near Llantrisant in Rhondda Cynon Taf, to replace East Glamorgan General Hospital.
Arts and literature
- Siân Phillips is appointed a CBE in the Queen's birthday honours list.
- Bryn Terfel's Faenol Festival is launched.
- The Welsh Music Foundation is established.
- Between May and August, over 100 rare maps are stolen from the National Library of Wales. A man later confesses to having stolen and sold them to collectors.
- Glyndŵr Award - Robin Huw Bowen
- National Eisteddfod of Wales: Chair - Llion Jones
- National Eisteddfod of Wales: Crown - Dylan Iorwerth
- National Eisteddfod of Wales: Prose Medal - Eurig Wyn, Tri Mochyn Bach
- Wales Book of the Year:
- Gwobr Goffa Daniel Owen - Geraint V. Jones, Cur y Nos
- Trezza Azzopardi - The Hiding Place
- Ruth Bidgood - Singing to Wolves
- Jon Gower - Big Fish
- Jerry Hunter - Soffestri’r Saeson
- Martin Johnes & Iain McLean - Aberfan: Government and Disasters
- Sheenagh Pugh - Stonelight
- Lorna Sage - Bad Blood
- Owen Sheers - The Blue Book
- Richard Churches - Requiem Mass
- Larry Goves - walking underground
- Racing Cars - A Bolt from the Blue
- Super Furry Animals - Mwng
- One of the Hollywood Ten, written and directed by Karl Francis
- The Testimony of Taliesin Jones with Jonathan Pryce and Matthew Rhys
- Rancid Aluminium, based on the novel by James Hawes, with Rhys Ifans, Keith Allen and Brian Hibbard.
- 102 Dalmatians, with Ioan Gruffudd and his future wife Alice Evans
- Moth (S4C)
- June - Golf: Celtic Manor Wales Open: European Tour tournament first played.
- Golf - Phillip Price is ranked 8th in the world.
- Snooker - Mark Williams defeats Matthew Stevens in an all-Welsh final at the World Snooker Championship.
- 19 January - Rex Willis, Wales international rugby union player, 75
- 19 February - Josef Herman, artist, 88
- 23 February - John Nevill, 5th Marquess of Abergavenny, 85
- 11 March - Will Roberts, painter, 92
- 7 April - Walter Vickery, Wales international rugby player, 90
- 12 April - Ronald Lockley, naturalist, 96
- 20 May - David Pearce, boxer, 41
- 28 May - Donald Davies, computer scientist and inventor, 75
- 30 May - Doris Hare, actress, 95
- 10 July - Dilwyn Lewis, designer, 76
- 19 July - Philip Jones, civil servant, 69
- 26 July - Albert Fear, Wales international rugby player, 92
- 17 September - Paula Yates, television presenter (born in Colwyn Bay), 41 (suicide)
- 25 September - R. S. Thomas, poet, 87
- 30 September - Howard Winstone, boxing champion, 61
- 11 November - Sir Alun Talfan Davies, judge, 87
- December - George Evans, footballer, 65
- 2 December - Rosemarie Frankland, former Miss World, 57 (drug overdose)
- 22 December - Harry Payne, Wales international rugby player, 93
- date unknown - Doug Rees, footballer