The 2001 Oklahoma State Cowboys football team represented Oklahoma State University in the 2001 NCAA Division I-A football season. Les Miles was in his first season at Oklahoma State as head coach. In the three years prior to Miles' arrival in Stillwater, the Cowboys finished 5–6, 5–6, and 3–8. Oklahoma State posted another losing record (4–7) in Miles' first season at the helm.
The final game of the season was a game to remember for the Cowboys. The Cowboys, amidst a losing season, went to Norman, Oklahoma to battle their state rivals, the Oklahoma Sooners. The Sooners had a possible National Championship on the line. The Cowboys won the game with a late catch by TD Bryant on third down and seven from the Oklahoma State 45 yard line. The catch went for 31 yards and set up the game-winning catch. Rashaun Woods then caught a touchdown pass from Josh Fields in the left corner of the end zone, giving the Cowboys the win.