March 28 – Pietro Aglieri writes a letter to the National Anti-mafia Prosecutor (DNA), Pierluigi Vigna, and the Chief Prosecutor of Palermo, Pietro Grasso to ask for negotiations. His proposal is that mafiosi would get more lenient penalties (in particular the relaxation of the article 41-bis prison regime) in return for recognizing the existence of Cosa Nostra and the authority of the Italian state. Aglieri had been approached by Vigna in 2000 in an attempt to get mafiosi to "dissociate" from Cosa Nostra — without becoming collaborators of justice — a method that was used successfully in the struggle against the Red Brigades. Ex-Red Brigades members could publicly recognise their errors without having to admit their own criminal responsibilities.
April 16 – Arrest of Antonino Giuffrè. He started feeding investigators information even before he agreed to turn state' witness (or pentito) in June, 2002. He is one of the most important mafia turncoats since Tommaso Buscetta in 1984. His collaboration has updated investigators' knowledge and provided a new interpretation for the sensitive issue of Cosa Nostra's relations with politics in the early 1990s. Apparently the arrest of Giuffrè was made possible by an anonymous phone call that seems to have been made by loyalists to the Mafia hardliners Totò Riina and Leoluca Bagarella. The purpose was to send a message to Bernardo Provenzano. The incarcerated bosses want something to be done about the harsh prison conditions (in particular the relaxation of the 41-bis incarceration regime) – and were believed to orchestrate a return to violence while serving multiple life sentences.
May 12 - Former Commission member Joseph Bonanno died at the age of 97. Bonanno had survived a shooting war against rebels in his own family and had survived after his plan to kill fellow commission members Carlo Gambino and Thomas Lucchese was revealed to the commission. Bonanno also lived to write a book about his life.
June - At a court appearance Leoluca Bagarella makes some thinly veiled threats to the Italian government, saying the Mafia is "tired of being manipulated by political forces." 
June 11 - Former Gambino crime family godfather John Gotti died of throat cancer in a prison hospital. Gotti's successor brother Peter was under indictment facing trial and would miss his brother's funeral services.
September 6 - Former Gambino crime family underboss and number two man under John Gotti, Salvatore Gravano, was sentenced to 20 years in prison for running a multimillion-dollar Ecstasy ring in Arizona. Gravano had admitted to committing 19 murders and his testimony was largely responsible for sending John Gotti and consigliere Frank LoCascio to prison for the rest of their lives.