Miami started the scoring with quarterback Ben Roethlisberger throwing a 28-yard touchdown pass to wide receiver Michael Larkin to post an early 7-0 lead. Later in the quarter, running back Cal Murray scored on a two-yard touchdown run to give the Redhawks a 14-0 lead. Ben Roethlisberger threw a 12-yard touchdown pass to wide receiver Martin Nance to give Miami a 21-0 first quarter lead.
Early in the second quarter, Lionel Gates scored a rushing touchdown for Louisville to make it 21-7. Ben Roethlisberger threw a 16-yard touchdown pass to Matt Brandt, and the lead was 28-7. Roethlisberger threw another touchdown pass to Michael Larkin, to give Miami a 35-7 lead. Louisville running back Michael Bush threw a 31-yard touchdown pass to wide receiver JR Russell to make it 35-14. Before halftime, quarterback Stefan LeFors threw a 2-yard touchdown pass to Russell, and the halftime score was Miami 35, Louisville 21.
Stefan Lefors threw a 24-yard touchdown pass to Russell in the third quarter, to make the score 35-28 Miami, but Louisville would get no closer. Mike Smith scored on a 3-yard touchdown run, and Matt Pusateri returned an interception 35 yards for a touchdown to make the final score 49-28.