The 2006 U.S. Men's Clay Court Championships was an Association of Tennis Professionals men's tennis tournament held in Houston, Texas in the United States. It was the 38th edition of the tournament and was held from April 10 to April 17. Mardy Fish won the singles title.
Mardy Fish defeated Jürgen Melzer 3–6, 6–4, 6–3
- It was Fish's only title of the year and the 5th of his career.
Michael Kohlmann / Alexander Waske defeated Julian Knowle / Jürgen Melzer 5–7, 6–4, [10–5]
- It was Kohlmann's only title of the year and the 4th of his career. It was Waske's 1st title of the year and the 1st of his career.