In the first quarter, Kentucky scored first on a 14-yard André Woodson touchdown pass to tight end Jacob Tamme. Florida State quarterback Drew Weatherford then scored on a 6-yard touchdown run. Kentucky built a 14-7 lead in the second quarter on a 13-yard touchdown pass from Woodson to Steve Johnson. Kentucky's defense then held Florida State to a turnover on downs inside the Kentucky five yard line, but immediately after that Florida State tied the game before halftime when Tony Carter intercepted a Woodson pass and returned it 24 yards for a touchdown.
Kentucky struck first in the third quarter when Woodson threw a 2-yard touchdown pass to Rafael Little. A 4-yard touchdown run by Tony Dixon boosted Kentucky's third quarter lead to 28-14. Florida State scored first in the fourth quarter with a 1-yard Weatherford touchdown run to make it 28-21. Woodson's 38-yard touchdown pass to Steve Johnson extended the Kentucky lead to 35-21. The game's final score was a 7-yard touchdown pass from Weatherford to Greg Carr to bring about the final tally: Kentucky 35, Florida State 28. The game appeared iced when Kentucky linebacker Micah Johnson intercepted a Weatherford pass with less than one minute remaining, but in attempting to return the interception Johnson fumbled the ball away and Florida State recovered. Florida State threw a pass into the end zone at the end of regulation but Kentucky defenders batted it down to seal the win.
The attendance of 68,661 set a new record for the Music City Bowl.
In Kentucky's 35–28 victory, 2006 game MVP André Woodson repeated as the 2007 MVP after throwing four touchdown passes. Florida State's Antone Smith gained a career-high 156 rushing yards; Kentucky's Rafael Little rushed for 152 yards and caught one touchdown pass, but he also fumbled twice. The win gave the Wildcats back-to-back bowl wins for the first time since 1952. It was also the first loss ever for the elder Bowden in a December bowl game.