The 2010 NCAA Division I baseball season, play of college baseball in the United States organized by the National Collegiate Athletic Association (NCAA) at the Division I level, began on February 19, 2010. The season progressed through the regular season, many conference tournaments and championship series, and concluded with the 2010 NCAA Division I Baseball Tournament and 2010 College World Series. The College World Series, which consisted of the eight remaining teams in the NCAA Tournament, was held in its annual location of Omaha, Nebraska. It was the final College World Series held at Omaha's Rosenblatt Stadium, which closed following the event. It concluded on June 30, 2010, with the final game of the best of three championship series. South Carolina defeated UCLA two games to none to claim their first championship, which was also South Carolina's first national championship in any men's sport.
The Texas Longhorns, defeated by LSU in the 2009 CWS championship series, entered the season ranked #1 in the major polls. Defending national champions LSU received a #2 ranking in the preseason.
The Pac-10 Conference champion Arizona State Sun Devils (47–8) ended the regular season ranked #1 in the USAToday/ESPN poll while the Virginia Cavaliers (47–11) finished #1 in the Baseball America poll. Preseason #1 Texas stumbled to an 0–3 Big 12 Tournament record to drop to #3 in both final polls. South Carolina finished the season as a unanimous #1 after winning its first College World Series.
The 2010 College World Series began on June 19, 2010 in Omaha, Nebraska. The South Carolina Gamecocks beat the UCLA Bruins 2 games to 0 in the best-of-three final to win the tournament. The College World Series was the 61st and final tournament held at Rosenblatt Stadium; starting in 2011, games will be played at TD Ameritrade Park Omaha. The following teams qualified for the CWS: