The 2010 Tunis Open was a professional tennis tournament played on red clay courts. It was part of the Tretorn SERIE+ of the 2010 ATP Challenger Tour. It took place in Tunis, Tunisia between April 26 and May 2, 2010.
- Rankings are as of April 19, 2010.
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
José Acasuso def. Daniel Brands, 6–3, 6–4
Jeff Coetzee / Kristof Vliegen def. James Cerretani / Adil Shamasdin, 7–6(3), 6–3