On 28 April 2012, first division club Lyon defeated semi-professional third-tierQuevilly 1–0 in the 2012 Coupe de France Final courtesy of a first half goal from Lisandro López to win its fifth Coupe de France title. The title is the club's first domestically since winning the same competition in 2008. The runners-up, Quevilly, alongside fellow National club Gazélec Ajaccio, were awarded the Petit Poucet Plaque, an award given to the best performing non-professional club in the Coupe de France.
In February 2011, it was reported by the French media that the French Football Federation had scheduled the 2011–12 edition of the Coupe de France final to be played on 5 May 2012. The date is significant because it would mark the 20th anniversary of the Furiani disaster, which occurred when a tribune at the Stade Armand Cesari in Furiani collapse during a Coupe de France semi-final match between SC Bastia and Marseille. The tragedy resulted in the death of 18 individuals and injuries to over 2,000. The resulting outcry and criticism of the decision to schedule the final on that date led to the Federation issuing a statement declaring that the official calendar for the competition had not been released, so the reports were only rumors. On 31 March 2011, the schedule was released and the date for the final was set for 28 April 2012.
In the 2010–11 Coupe de France, a seventh round match between Tourcoing and Viry-Châtillon was abandoned after 30 minutes following an altercation between two opposing players, which resulted in a brawl breaking out and dozens of spectators invading the field of play. The brawl led to a player losing consciousness and an assistant referee suffering a back injury after being hit with debris. The incident required police and firefighter intervention and, despite handing out four red cards as a result of the altercation, the referee called the match off after repeated failed attempts to restore calm. On 3 December 2010, the French Football Federation ruled that, due to the incidents that occurred in the match, both clubs would be disbarred from this year's competition, effective immediately. Both clubs will also be ineligible to appear in the 2011–12 competition, as well.
All of the teams that enter the competition, but are not members of Ligue 1 or Ligue 2, have to compete in the regional qualifying rounds. The regional qualifying rounds determine the number of regional clubs that will earn spots in the 7th round and normally lasts six rounds.
The draw for the eighth round of the Coupe de France was held on 23 November 2011 at the headquarters of the French Football Federation (FFF), and was conducted by former French internationalsLuis Fernández and Laurent Robert. The round featured the 88 winners of the seventh round. The matches was played through 9–12 December.
The draw for the Round of 64 of the Coupe de France was held on 12 December 2011 at the headquarters of Crédit Agricole, a main sponsor of the competition, in Amiens. The round featured the 44 winners of the eighth round, as well as the 20 clubs who play in Ligue 1. The matches was played through 6–9 January 2012.
Similar to the previous round, following the draw, several amateur clubs announced that they would be hosting their matches at larger venues. On 11 January, Vendée Luçon officials announced that the club's match against Lyon would be contested at the Stade de la Beaujoire in nearby Nantes. Hours later, it was confirmed that the match between Sablé-sur-Sarthe and Paris Saint-Germain would be played at the MMArena in Le Mans.
On 6 February, the French Football Federation announced that three matches would be rescheduled due to inclement weather. The Dijon–Paris Saint-Germain and Bourg-Péronnas–Marseille match was rescheduled for 15 February, while the Quevilly–Orléans will be played on 21 February.
^The qualifying rounds are organized by the regions' respective regional and departmental leagues. Each regions' qualifying rounds lasts six rounds in order to determine the regional and departmental clubs that will earn a berth in the seventh round.